Indole diterpenoid synthetic studies. The total synthesis of (+)-nodulisporic acid F

Amos B. Smith, Akin H. Davulcu, László Kürti

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

A stereocontrolled total synthesis of (+)-nodulisporic acid F, the simplest member of a family of novel ectoparasiticidal agents, has been achieved. Highlights of the effective modular synthetic strategy include anionic union of a tricyclic lactone with o-toluidine via our 2-substituted indole synthetic protocol, an optimized C-ring construction protocol, and a late-stage installation of the α,β-unsaturated carboxylic acid side chain via the B-alkyl Suzuki-Miyaura cross-coupling tactic.

Original languageEnglish (US)
Pages (from-to)1665-1668
Number of pages4
JournalOrganic Letters
Volume8
Issue number8
DOIs
Publication statusPublished - Apr 13 2006

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ASJC Scopus subject areas

  • Molecular Medicine

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