Induction of conditioned taste aversion in rats by GABA or other amino acids

Jean K. Tews, Joyce J. Repa, Alfred E. Harper

Research output: Contribution to journalArticle

Abstract

GABA included in the diet is known to reduce food intake and growth of rats fed a low protein diet. Experiments were designed to determine if GABA or other small neutral amino acids would affect food intake if they were administered separately from the diet, and if such amino acids could induce a conditioned taste aversion (CTA) to saccharin. Intubated or injected GABA or α-aminoisobutyric acid (AIB), a non-metabolizable isomer of GABA, reduced food intake. When rats were fed a low protein diet, IP injection of threonine (2 mmoles/200 g rat) induced CTA but did not depress food intake; serine (3 mmoles/200 g rat) induced CTA and caused only a small reduction in food intake. Another isomer, α-amino-n-butyric acid did not affect food intake or induce CTA at the tested concentrations. Adaptation to a high protein diet, which increases enzymatic degradation of many amino acids including GABA and serine, lessened severity of GABA-induced CTA and eliminated that caused by serine. CTA to saccharin can be induced by certain amino acids; the mechanism is unknown but may involve malaise or other adverse sensations.

Original languageEnglish (US)
Pages (from-to)591-597
Number of pages7
JournalPhysiology and Behavior
Volume42
Issue number6
DOIs
StatePublished - 1988

Fingerprint

gamma-Aminobutyric Acid
Eating
Amino Acids
Serine
Saccharin
Protein-Restricted Diet
Diet
Aminoisobutyric Acids
Neutral Amino Acids
Butyric Acid
Threonine
Injections
Growth
Proteins

Keywords

  • Amino acids
  • Behavior
  • Conditioned taste aversion
  • Dietary protein
  • Drinking
  • GABA
  • Lithium chloride
  • Saccharin
  • Small neutral amino acids

ASJC Scopus subject areas

  • Physiology (medical)
  • Behavioral Neuroscience

Cite this

Induction of conditioned taste aversion in rats by GABA or other amino acids. / Tews, Jean K.; Repa, Joyce J.; Harper, Alfred E.

In: Physiology and Behavior, Vol. 42, No. 6, 1988, p. 591-597.

Research output: Contribution to journalArticle

Tews, Jean K. ; Repa, Joyce J. ; Harper, Alfred E. / Induction of conditioned taste aversion in rats by GABA or other amino acids. In: Physiology and Behavior. 1988 ; Vol. 42, No. 6. pp. 591-597.
@article{2bafd77ff3fb40d28744220f0d916a69,
title = "Induction of conditioned taste aversion in rats by GABA or other amino acids",
abstract = "GABA included in the diet is known to reduce food intake and growth of rats fed a low protein diet. Experiments were designed to determine if GABA or other small neutral amino acids would affect food intake if they were administered separately from the diet, and if such amino acids could induce a conditioned taste aversion (CTA) to saccharin. Intubated or injected GABA or α-aminoisobutyric acid (AIB), a non-metabolizable isomer of GABA, reduced food intake. When rats were fed a low protein diet, IP injection of threonine (2 mmoles/200 g rat) induced CTA but did not depress food intake; serine (3 mmoles/200 g rat) induced CTA and caused only a small reduction in food intake. Another isomer, α-amino-n-butyric acid did not affect food intake or induce CTA at the tested concentrations. Adaptation to a high protein diet, which increases enzymatic degradation of many amino acids including GABA and serine, lessened severity of GABA-induced CTA and eliminated that caused by serine. CTA to saccharin can be induced by certain amino acids; the mechanism is unknown but may involve malaise or other adverse sensations.",
keywords = "Amino acids, Behavior, Conditioned taste aversion, Dietary protein, Drinking, GABA, Lithium chloride, Saccharin, Small neutral amino acids",
author = "Tews, {Jean K.} and Repa, {Joyce J.} and Harper, {Alfred E.}",
year = "1988",
doi = "10.1016/0031-9384(88)90162-X",
language = "English (US)",
volume = "42",
pages = "591--597",
journal = "Physiology and Behavior",
issn = "0031-9384",
publisher = "Elsevier Inc.",
number = "6",

}

TY - JOUR

T1 - Induction of conditioned taste aversion in rats by GABA or other amino acids

AU - Tews, Jean K.

AU - Repa, Joyce J.

AU - Harper, Alfred E.

PY - 1988

Y1 - 1988

N2 - GABA included in the diet is known to reduce food intake and growth of rats fed a low protein diet. Experiments were designed to determine if GABA or other small neutral amino acids would affect food intake if they were administered separately from the diet, and if such amino acids could induce a conditioned taste aversion (CTA) to saccharin. Intubated or injected GABA or α-aminoisobutyric acid (AIB), a non-metabolizable isomer of GABA, reduced food intake. When rats were fed a low protein diet, IP injection of threonine (2 mmoles/200 g rat) induced CTA but did not depress food intake; serine (3 mmoles/200 g rat) induced CTA and caused only a small reduction in food intake. Another isomer, α-amino-n-butyric acid did not affect food intake or induce CTA at the tested concentrations. Adaptation to a high protein diet, which increases enzymatic degradation of many amino acids including GABA and serine, lessened severity of GABA-induced CTA and eliminated that caused by serine. CTA to saccharin can be induced by certain amino acids; the mechanism is unknown but may involve malaise or other adverse sensations.

AB - GABA included in the diet is known to reduce food intake and growth of rats fed a low protein diet. Experiments were designed to determine if GABA or other small neutral amino acids would affect food intake if they were administered separately from the diet, and if such amino acids could induce a conditioned taste aversion (CTA) to saccharin. Intubated or injected GABA or α-aminoisobutyric acid (AIB), a non-metabolizable isomer of GABA, reduced food intake. When rats were fed a low protein diet, IP injection of threonine (2 mmoles/200 g rat) induced CTA but did not depress food intake; serine (3 mmoles/200 g rat) induced CTA and caused only a small reduction in food intake. Another isomer, α-amino-n-butyric acid did not affect food intake or induce CTA at the tested concentrations. Adaptation to a high protein diet, which increases enzymatic degradation of many amino acids including GABA and serine, lessened severity of GABA-induced CTA and eliminated that caused by serine. CTA to saccharin can be induced by certain amino acids; the mechanism is unknown but may involve malaise or other adverse sensations.

KW - Amino acids

KW - Behavior

KW - Conditioned taste aversion

KW - Dietary protein

KW - Drinking

KW - GABA

KW - Lithium chloride

KW - Saccharin

KW - Small neutral amino acids

UR - http://www.scopus.com/inward/record.url?scp=0023946293&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023946293&partnerID=8YFLogxK

U2 - 10.1016/0031-9384(88)90162-X

DO - 10.1016/0031-9384(88)90162-X

M3 - Article

VL - 42

SP - 591

EP - 597

JO - Physiology and Behavior

JF - Physiology and Behavior

SN - 0031-9384

IS - 6

ER -