Induction of hypertriglyceridemia in rabbits by thermal injury: I. Time course of elevated plasma triglyceride levels

G. L. Vega, C. R. Baxter

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Thermal injury was produced in rabbits to determine (1) whether hypertriglyceridemia was inducible by thermal injury and, if so, (2) what was its time course and (3) how were the levels of apolipoproteins B, E, and A-I affected. In this study, seven New Zealand-specific pathogen-free male rabbits were inflicted with a burn to 27% of the total body surface area; another seven rabbits underwent a sham procedure. Plasma triglyceride levels rose markedly in the thermally injured group, and the hypertriglyceridemia persisted for ten days. Total plasma apolipoprotein B levels increased markedly by three days postburn and remained elevated for a period longer than the hypertriglyceridemia. In contrast, apolipoprotein E levels slowly increased, reaching a peak by day 10, and declined thereafter. Plasma levels of apolipoprotein A-I increased rapidly and remained elevated for two months. Thus, hypertriglyceridemia and concomitant changes in levels of apolipoproteins B, E, and A-I could be induced in rabbits by thermal injury. Plasma triglyceride levels were elevated for some time and then returned to normal, whereas apolipoprotein levels remained elevated for a longer time. These abnormalities may impair normal lipid transport in the postburn phase.

Original languageEnglish (US)
Pages (from-to)266-270
Number of pages5
JournalJournal of Burn Care and Rehabilitation
Volume9
Issue number3
StatePublished - 1988

Fingerprint

Hypertriglyceridemia
Apolipoproteins B
Triglycerides
Apolipoproteins E
Hot Temperature
Apolipoproteins A
Rabbits
Wounds and Injuries
Specific Pathogen-Free Organisms
Apolipoproteins
Body Surface Area
Apolipoprotein A-I
New Zealand
Lipids

ASJC Scopus subject areas

  • Emergency Medicine
  • Rehabilitation
  • Surgery
  • Nursing(all)
  • Health Professions(all)

Cite this

@article{6acaa385af024d02866c6e0f8082f285,
title = "Induction of hypertriglyceridemia in rabbits by thermal injury: I. Time course of elevated plasma triglyceride levels",
abstract = "Thermal injury was produced in rabbits to determine (1) whether hypertriglyceridemia was inducible by thermal injury and, if so, (2) what was its time course and (3) how were the levels of apolipoproteins B, E, and A-I affected. In this study, seven New Zealand-specific pathogen-free male rabbits were inflicted with a burn to 27{\%} of the total body surface area; another seven rabbits underwent a sham procedure. Plasma triglyceride levels rose markedly in the thermally injured group, and the hypertriglyceridemia persisted for ten days. Total plasma apolipoprotein B levels increased markedly by three days postburn and remained elevated for a period longer than the hypertriglyceridemia. In contrast, apolipoprotein E levels slowly increased, reaching a peak by day 10, and declined thereafter. Plasma levels of apolipoprotein A-I increased rapidly and remained elevated for two months. Thus, hypertriglyceridemia and concomitant changes in levels of apolipoproteins B, E, and A-I could be induced in rabbits by thermal injury. Plasma triglyceride levels were elevated for some time and then returned to normal, whereas apolipoprotein levels remained elevated for a longer time. These abnormalities may impair normal lipid transport in the postburn phase.",
author = "Vega, {G. L.} and Baxter, {C. R.}",
year = "1988",
language = "English (US)",
volume = "9",
pages = "266--270",
journal = "Journal of Burn Care and Research",
issn = "1559-047X",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - Induction of hypertriglyceridemia in rabbits by thermal injury

T2 - I. Time course of elevated plasma triglyceride levels

AU - Vega, G. L.

AU - Baxter, C. R.

PY - 1988

Y1 - 1988

N2 - Thermal injury was produced in rabbits to determine (1) whether hypertriglyceridemia was inducible by thermal injury and, if so, (2) what was its time course and (3) how were the levels of apolipoproteins B, E, and A-I affected. In this study, seven New Zealand-specific pathogen-free male rabbits were inflicted with a burn to 27% of the total body surface area; another seven rabbits underwent a sham procedure. Plasma triglyceride levels rose markedly in the thermally injured group, and the hypertriglyceridemia persisted for ten days. Total plasma apolipoprotein B levels increased markedly by three days postburn and remained elevated for a period longer than the hypertriglyceridemia. In contrast, apolipoprotein E levels slowly increased, reaching a peak by day 10, and declined thereafter. Plasma levels of apolipoprotein A-I increased rapidly and remained elevated for two months. Thus, hypertriglyceridemia and concomitant changes in levels of apolipoproteins B, E, and A-I could be induced in rabbits by thermal injury. Plasma triglyceride levels were elevated for some time and then returned to normal, whereas apolipoprotein levels remained elevated for a longer time. These abnormalities may impair normal lipid transport in the postburn phase.

AB - Thermal injury was produced in rabbits to determine (1) whether hypertriglyceridemia was inducible by thermal injury and, if so, (2) what was its time course and (3) how were the levels of apolipoproteins B, E, and A-I affected. In this study, seven New Zealand-specific pathogen-free male rabbits were inflicted with a burn to 27% of the total body surface area; another seven rabbits underwent a sham procedure. Plasma triglyceride levels rose markedly in the thermally injured group, and the hypertriglyceridemia persisted for ten days. Total plasma apolipoprotein B levels increased markedly by three days postburn and remained elevated for a period longer than the hypertriglyceridemia. In contrast, apolipoprotein E levels slowly increased, reaching a peak by day 10, and declined thereafter. Plasma levels of apolipoprotein A-I increased rapidly and remained elevated for two months. Thus, hypertriglyceridemia and concomitant changes in levels of apolipoproteins B, E, and A-I could be induced in rabbits by thermal injury. Plasma triglyceride levels were elevated for some time and then returned to normal, whereas apolipoprotein levels remained elevated for a longer time. These abnormalities may impair normal lipid transport in the postburn phase.

UR - http://www.scopus.com/inward/record.url?scp=0023784206&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023784206&partnerID=8YFLogxK

M3 - Article

C2 - 3138242

AN - SCOPUS:0023784206

VL - 9

SP - 266

EP - 270

JO - Journal of Burn Care and Research

JF - Journal of Burn Care and Research

SN - 1559-047X

IS - 3

ER -