Infection caused by Francisella philomiragia (formerly Yersinia philomiragia). A newly recognized human pathogen

J. D. Wenger, D. G. Hollis, R. E. Weaver, C. N. Baker, G. R. Brown, D. J. Brenner, C. V. Broome

Research output: Contribution to journalArticle

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Abstract

We evaluated the clinical characteristics of patients with Francisella philomiragia (formerly Yersinia philomiragia) isolated from normally sterile sites. Isolates from 14 patients were received by the Centers for Disease Control between 1975 and 1987: 9 were from blood; 2 from lung biopsies; and 1 each from pleural, peritoneal, and cerebrospinal fluid. Underlying problems included chronic granulomatous disease in 5 patients, near-drowning in 5, and a myeloproliferative disease in 2. All 13 patients for whom records were available had a febrile syndrome compatible with bacterial infection. Pneumonia and fever-bacteremia were the commonest clinical syndromes reported. In 7 cases, F. philomiragia was the only sterile-site isolate, and the clinical syndrome did not resolve without appropriate antibiotics. Familiarity with this organism is important because of its ability to cause serious disease in chronic granulomatous disease and near-drowning patients. Further study may yield new insights into pathogenic and host defense mechanisms.

Original languageEnglish (US)
Pages (from-to)888-892
Number of pages5
JournalAnnals of Internal Medicine
Volume110
Issue number11
StatePublished - 1989

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Francisella
Yersinia
Near Drowning
Chronic Granulomatous Disease
Infection
Fever
Aptitude
Ascitic Fluid
Defense Mechanisms
Centers for Disease Control and Prevention (U.S.)
Bacteremia
Bacterial Infections
Cerebrospinal Fluid
Pneumonia
Anti-Bacterial Agents
Biopsy
Lung

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Wenger, J. D., Hollis, D. G., Weaver, R. E., Baker, C. N., Brown, G. R., Brenner, D. J., & Broome, C. V. (1989). Infection caused by Francisella philomiragia (formerly Yersinia philomiragia). A newly recognized human pathogen. Annals of Internal Medicine, 110(11), 888-892.

Infection caused by Francisella philomiragia (formerly Yersinia philomiragia). A newly recognized human pathogen. / Wenger, J. D.; Hollis, D. G.; Weaver, R. E.; Baker, C. N.; Brown, G. R.; Brenner, D. J.; Broome, C. V.

In: Annals of Internal Medicine, Vol. 110, No. 11, 1989, p. 888-892.

Research output: Contribution to journalArticle

Wenger, JD, Hollis, DG, Weaver, RE, Baker, CN, Brown, GR, Brenner, DJ & Broome, CV 1989, 'Infection caused by Francisella philomiragia (formerly Yersinia philomiragia). A newly recognized human pathogen', Annals of Internal Medicine, vol. 110, no. 11, pp. 888-892.
Wenger, J. D. ; Hollis, D. G. ; Weaver, R. E. ; Baker, C. N. ; Brown, G. R. ; Brenner, D. J. ; Broome, C. V. / Infection caused by Francisella philomiragia (formerly Yersinia philomiragia). A newly recognized human pathogen. In: Annals of Internal Medicine. 1989 ; Vol. 110, No. 11. pp. 888-892.
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