Infiltrating macrophages are broadly activated at the early stage to support acute skeletal muscle injury repair

Xingyu Wang, Wanming Zhao, Richard M. Ransohoff, Lan Zhou

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Acute skeletal muscle injury repair requires an adequate inflammatory response predominated by macrophage infiltration. We studied the activation of infiltrating macrophages by analyzing the expression of M1/M2 signature genes. Most of the intramuscular macrophages were Ly6C hi at day 1 after BaCl 2 injection, while many were Ly6C lo at day 3. Ly6C hi macrophages at day 1 expressed a high level of both M1 and M2 genes, and the Ly6C hi and Ly6C lo macrophages at day 3 expressed a similar level of many M1/M2 genes. Infiltrating macrophages are broadly activated rather than polarized at the early stage to support acute skeletal muscle injury repair.

Original languageEnglish (US)
Pages (from-to)55-66
Number of pages12
JournalJournal of Neuroimmunology
Volume317
DOIs
StatePublished - Apr 15 2018

Keywords

  • M1/M2
  • Macrophage activation
  • Muscle regeneration
  • Skeletal muscle injury

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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