Infiltrating macrophages are broadly activated at the early stage to support acute skeletal muscle injury repair

Xingyu Wang, Wanming Zhao, Richard M. Ransohoff, Lan Zhou

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Acute skeletal muscle injury repair requires an adequate inflammatory response predominated by macrophage infiltration. We studied the activation of infiltrating macrophages by analyzing the expression of M1/M2 signature genes. Most of the intramuscular macrophages were Ly6Chi at day 1 after BaCl2 injection, while many were Ly6Clo at day 3. Ly6Chi macrophages at day 1 expressed a high level of both M1 and M2 genes, and the Ly6Chi and Ly6Clo macrophages at day 3 expressed a similar level of many M1/M2 genes. Infiltrating macrophages are broadly activated rather than polarized at the early stage to support acute skeletal muscle injury repair.

Original languageEnglish (US)
JournalJournal of Neuroimmunology
DOIs
StateAccepted/In press - Jan 1 2018

Keywords

  • M1/M2
  • Macrophage activation
  • Muscle regeneration
  • Skeletal muscle injury

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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