Inflammasomes and intestinal tumorigenesis

Md Hasan Zaki, Mohamed Lamkanfi, Thirumala Devi Kanneganti

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations

Abstract

Colorectal cancer is a major health problem in developed countries. Chronic intestinal inflammation predisposes individuals to the development of colorectal cancer. The intracellular NOD-like receptors (NLRs) have emerged as crucial regulators of intestinal inflammation and colorectal tumorigenesis. Activation of several NLRs leads to the formation of a protein complex called the inflammasome, which then triggers the activation of the cysteine protease caspase-1 and the downstream maturation and secretion of the inflammatory cytokines interleukin (IL)-1β and -18. Defective inflammasome signaling in the gut contributes to colitis and colorectal tumorigenesis by increasing the permeability of the epithelial barrier, dysregulating the proliferation of epithelial cells, and inducing oncogenic mediators. In this review, we discuss our current knowledge on how the inflammasome protects against colorectal tumorigenesis.

Original languageEnglish (US)
Pages (from-to)e71-e78
JournalDrug Discovery Today: Disease Mechanisms
Volume8
Issue number3-4
DOIs
StatePublished - Jan 1 2011

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

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