Influence of age on pain perception in acute myocardial ischemia: A possible cause for delayed treatment in elderly patients

H. Rittger, J. Rieber, O. A. Breithardt, M. Dücker, M. Schmidt, S. Abbara, A. M. Sinha, A. Jakob, G. Nölker, J. Brachmann

Research output: Contribution to journalArticle

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Abstract

Background: Elderly patients tend to seek later for medical help during myocardial infarction. This may be caused by impaired pain perception with ageing. The aim of our study was to prospectively evaluate age-dependent differences in pain perception during temporary induced coronary ischemia. Methods: In 102 patients (68 male, age 68 ± 11 years) undergoing percutaneous coronary intervention, ischemia was induced by balloon inflation for up to 120 s. Time to onset of perceived pain, pain characteristics and pain severity (0 = no pain, 100 = worst pain possible) was registered. This was repeated twice to evaluate ischemic preconditioning. A 12 lead ECG-tracing was simultaneously recorded. Patients were divided by their median age into 2 groups with comparable demographics: ≤ 69 years (group 1) and > 69 years (group 2). Results: Group 1 patients demonstrated earlier onset of pain (most apparent during the second inflation: 31 ± 15 s vs. 46 ± 26 s; p < 0.001), and greater pain severity (inflation #1: 64 ± 21 vs. 51 ± 25 [p = 0.017]; #2: 66 ± 23 vs.52 ± 27 [p = 0.008]; #3: 63 ± 23 vs. 54 ± 24 [p = 0.085]). ST-changes did not differ (0.24 ± 0.10 vs. 0.20 ± 0.14, [p = 0.18]; 0.27 ± 0.17 vs. 0.20 ± 0.14, [p = 0.11]; 0.19 ± 0.13 vs. 0.16 ± 0.09; [p = 0.32]). Time from occlusion to onset of ECG changes did not differ between the groups, but increased with repetitive inflations (inflation #1: 29 ± 11 s vs. 29 ± 11 s; #2: 31 ± 14 vs. 33 ± 11; #3: 39 ± 21 vs. 40 ± 15 s [increase p = 0.017; p < 0.001]). Conclusion: These data suggest that the perception of pain from myocardial ischemia in the elderly is significantly less severe and delayed compared to younger patients.

Original languageEnglish (US)
Pages (from-to)63-67
Number of pages5
JournalInternational Journal of Cardiology
Volume149
Issue number1
DOIs
StatePublished - May 19 2011

Fingerprint

Pain Perception
Myocardial Ischemia
Economic Inflation
Pain
Therapeutics
Electrocardiography
Ischemia
Ischemic Preconditioning
Percutaneous Coronary Intervention
Myocardial Infarction
Demography

Keywords

  • Acute myocardial infarction
  • Clinical symptoms
  • Elderly patients
  • Reduced pain perception
  • Time delay

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Influence of age on pain perception in acute myocardial ischemia : A possible cause for delayed treatment in elderly patients. / Rittger, H.; Rieber, J.; Breithardt, O. A.; Dücker, M.; Schmidt, M.; Abbara, S.; Sinha, A. M.; Jakob, A.; Nölker, G.; Brachmann, J.

In: International Journal of Cardiology, Vol. 149, No. 1, 19.05.2011, p. 63-67.

Research output: Contribution to journalArticle

Rittger, H, Rieber, J, Breithardt, OA, Dücker, M, Schmidt, M, Abbara, S, Sinha, AM, Jakob, A, Nölker, G & Brachmann, J 2011, 'Influence of age on pain perception in acute myocardial ischemia: A possible cause for delayed treatment in elderly patients', International Journal of Cardiology, vol. 149, no. 1, pp. 63-67. https://doi.org/10.1016/j.ijcard.2009.11.046
Rittger, H. ; Rieber, J. ; Breithardt, O. A. ; Dücker, M. ; Schmidt, M. ; Abbara, S. ; Sinha, A. M. ; Jakob, A. ; Nölker, G. ; Brachmann, J. / Influence of age on pain perception in acute myocardial ischemia : A possible cause for delayed treatment in elderly patients. In: International Journal of Cardiology. 2011 ; Vol. 149, No. 1. pp. 63-67.
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abstract = "Background: Elderly patients tend to seek later for medical help during myocardial infarction. This may be caused by impaired pain perception with ageing. The aim of our study was to prospectively evaluate age-dependent differences in pain perception during temporary induced coronary ischemia. Methods: In 102 patients (68 male, age 68 ± 11 years) undergoing percutaneous coronary intervention, ischemia was induced by balloon inflation for up to 120 s. Time to onset of perceived pain, pain characteristics and pain severity (0 = no pain, 100 = worst pain possible) was registered. This was repeated twice to evaluate ischemic preconditioning. A 12 lead ECG-tracing was simultaneously recorded. Patients were divided by their median age into 2 groups with comparable demographics: ≤ 69 years (group 1) and > 69 years (group 2). Results: Group 1 patients demonstrated earlier onset of pain (most apparent during the second inflation: 31 ± 15 s vs. 46 ± 26 s; p < 0.001), and greater pain severity (inflation #1: 64 ± 21 vs. 51 ± 25 [p = 0.017]; #2: 66 ± 23 vs.52 ± 27 [p = 0.008]; #3: 63 ± 23 vs. 54 ± 24 [p = 0.085]). ST-changes did not differ (0.24 ± 0.10 vs. 0.20 ± 0.14, [p = 0.18]; 0.27 ± 0.17 vs. 0.20 ± 0.14, [p = 0.11]; 0.19 ± 0.13 vs. 0.16 ± 0.09; [p = 0.32]). Time from occlusion to onset of ECG changes did not differ between the groups, but increased with repetitive inflations (inflation #1: 29 ± 11 s vs. 29 ± 11 s; #2: 31 ± 14 vs. 33 ± 11; #3: 39 ± 21 vs. 40 ± 15 s [increase p = 0.017; p < 0.001]). Conclusion: These data suggest that the perception of pain from myocardial ischemia in the elderly is significantly less severe and delayed compared to younger patients.",
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AU - Rieber, J.

AU - Breithardt, O. A.

AU - Dücker, M.

AU - Schmidt, M.

AU - Abbara, S.

AU - Sinha, A. M.

AU - Jakob, A.

AU - Nölker, G.

AU - Brachmann, J.

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N2 - Background: Elderly patients tend to seek later for medical help during myocardial infarction. This may be caused by impaired pain perception with ageing. The aim of our study was to prospectively evaluate age-dependent differences in pain perception during temporary induced coronary ischemia. Methods: In 102 patients (68 male, age 68 ± 11 years) undergoing percutaneous coronary intervention, ischemia was induced by balloon inflation for up to 120 s. Time to onset of perceived pain, pain characteristics and pain severity (0 = no pain, 100 = worst pain possible) was registered. This was repeated twice to evaluate ischemic preconditioning. A 12 lead ECG-tracing was simultaneously recorded. Patients were divided by their median age into 2 groups with comparable demographics: ≤ 69 years (group 1) and > 69 years (group 2). Results: Group 1 patients demonstrated earlier onset of pain (most apparent during the second inflation: 31 ± 15 s vs. 46 ± 26 s; p < 0.001), and greater pain severity (inflation #1: 64 ± 21 vs. 51 ± 25 [p = 0.017]; #2: 66 ± 23 vs.52 ± 27 [p = 0.008]; #3: 63 ± 23 vs. 54 ± 24 [p = 0.085]). ST-changes did not differ (0.24 ± 0.10 vs. 0.20 ± 0.14, [p = 0.18]; 0.27 ± 0.17 vs. 0.20 ± 0.14, [p = 0.11]; 0.19 ± 0.13 vs. 0.16 ± 0.09; [p = 0.32]). Time from occlusion to onset of ECG changes did not differ between the groups, but increased with repetitive inflations (inflation #1: 29 ± 11 s vs. 29 ± 11 s; #2: 31 ± 14 vs. 33 ± 11; #3: 39 ± 21 vs. 40 ± 15 s [increase p = 0.017; p < 0.001]). Conclusion: These data suggest that the perception of pain from myocardial ischemia in the elderly is significantly less severe and delayed compared to younger patients.

AB - Background: Elderly patients tend to seek later for medical help during myocardial infarction. This may be caused by impaired pain perception with ageing. The aim of our study was to prospectively evaluate age-dependent differences in pain perception during temporary induced coronary ischemia. Methods: In 102 patients (68 male, age 68 ± 11 years) undergoing percutaneous coronary intervention, ischemia was induced by balloon inflation for up to 120 s. Time to onset of perceived pain, pain characteristics and pain severity (0 = no pain, 100 = worst pain possible) was registered. This was repeated twice to evaluate ischemic preconditioning. A 12 lead ECG-tracing was simultaneously recorded. Patients were divided by their median age into 2 groups with comparable demographics: ≤ 69 years (group 1) and > 69 years (group 2). Results: Group 1 patients demonstrated earlier onset of pain (most apparent during the second inflation: 31 ± 15 s vs. 46 ± 26 s; p < 0.001), and greater pain severity (inflation #1: 64 ± 21 vs. 51 ± 25 [p = 0.017]; #2: 66 ± 23 vs.52 ± 27 [p = 0.008]; #3: 63 ± 23 vs. 54 ± 24 [p = 0.085]). ST-changes did not differ (0.24 ± 0.10 vs. 0.20 ± 0.14, [p = 0.18]; 0.27 ± 0.17 vs. 0.20 ± 0.14, [p = 0.11]; 0.19 ± 0.13 vs. 0.16 ± 0.09; [p = 0.32]). Time from occlusion to onset of ECG changes did not differ between the groups, but increased with repetitive inflations (inflation #1: 29 ± 11 s vs. 29 ± 11 s; #2: 31 ± 14 vs. 33 ± 11; #3: 39 ± 21 vs. 40 ± 15 s [increase p = 0.017; p < 0.001]). Conclusion: These data suggest that the perception of pain from myocardial ischemia in the elderly is significantly less severe and delayed compared to younger patients.

KW - Acute myocardial infarction

KW - Clinical symptoms

KW - Elderly patients

KW - Reduced pain perception

KW - Time delay

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