Influence of ketorolac tromethamine on clot elastic strength in humans as assessed by thromboelastography

Study Objective: To evaluate the effect of ketorolac tromethamine on coagulation using thrombelastography (TEG). Design: TEGs were performed in each patient before and after ketorolac administration. Each patient's predrug results were used as control measurements for comparison with the postdrug results. Setting: Medical center surgical unit. Patients: Twenty ASA physical status I and II patients undergoing minor elective surgery; 12 healthy volunteers. Interventions: TEGs were performed in all subjects before and 60 minutes after the intramuscular (IM) administration of ketorolac tromethamine 60 mg. Ten surgical patients were studied in the intraoperative period, and 10 surgical patients were studied in the postoperative period. The 12 healthy volunteers did not undergo a surgical procedure. Measurements and Main Results: Specific parameters assessed from, the TEGS were reaction time (R time), coagulation time (RK time), clot formation rate (angle of deflection), and maximum clot strength (maximum amplitude of deflection). Ketorolac administration did not cause statistically significant changes in these parameters in any of the three groups studied. Conclusions: IM administration of ketorolac tromethamine 60 mg did not significantly alter the speed of formation or viscoelastic strength of clots as measured by TEG. These results provide additional support for prior clinical studies confirming the safety of ketorolac administration in the perioperative period.