Influence of probe pressure on the diffuse correlation spectroscopy blood flow signal: Extra-cerebral contributions

Rickson C. Mesquita, Steven S. Schenkel, David L. Minkoff, Xiangping Lu, Christopher G. Favilla, Patrick M. Vora, David R. Busch, Malavika Chandra, Joel H. Greenberg, John A. Detre, A. G. Yodh

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

A pilot study explores relative contributions of extra-cerebral (scalp/skull) versus brain (cerebral) tissues to the blood flow index determined by diffuse correlation spectroscopy (DCS). Microvascular DCS flow measurements were made on the head during baseline and breath-holding/hyperventilation tasks, both with and without pressure. Baseline (resting) data enabled estimation of extra-cerebral flow signals and their pressure dependencies. A simple two-component model was used to derive baseline and activated cerebral blood flow (CBF) signals, and the DCS flow indices were also cross-correlated with concurrent Transcranial Doppler Ultrasound (TCD) blood velocity measurements. The study suggests new pressure-dependent experimental paradigms for elucidation of blood flow contributions from extra-cerebral and cerebral tissues.

Original languageEnglish (US)
Pages (from-to)978-994
Number of pages17
JournalBiomedical Optics Express
Volume4
Issue number7
DOIs
StatePublished - Jan 1 2013
Externally publishedYes

ASJC Scopus subject areas

  • Biotechnology
  • Atomic and Molecular Physics, and Optics

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    Mesquita, R. C., Schenkel, S. S., Minkoff, D. L., Lu, X., Favilla, C. G., Vora, P. M., Busch, D. R., Chandra, M., Greenberg, J. H., Detre, J. A., & Yodh, A. G. (2013). Influence of probe pressure on the diffuse correlation spectroscopy blood flow signal: Extra-cerebral contributions. Biomedical Optics Express, 4(7), 978-994. https://doi.org/10.1364/BOE.4.000978