Abstract
A pilot study explores relative contributions of extra-cerebral (scalp/skull) versus brain (cerebral) tissues to the blood flow index determined by diffuse correlation spectroscopy (DCS). Microvascular DCS flow measurements were made on the head during baseline and breath-holding/hyperventilation tasks, both with and without pressure. Baseline (resting) data enabled estimation of extra-cerebral flow signals and their pressure dependencies. A simple two-component model was used to derive baseline and activated cerebral blood flow (CBF) signals, and the DCS flow indices were also cross-correlated with concurrent Transcranial Doppler Ultrasound (TCD) blood velocity measurements. The study suggests new pressure-dependent experimental paradigms for elucidation of blood flow contributions from extra-cerebral and cerebral tissues.
Original language | English (US) |
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Pages (from-to) | 978-994 |
Number of pages | 17 |
Journal | Biomedical Optics Express |
Volume | 4 |
Issue number | 7 |
DOIs | |
State | Published - 2013 |
Externally published | Yes |
ASJC Scopus subject areas
- Biotechnology
- Atomic and Molecular Physics, and Optics