Influence of suspension hypokinesia on rat soleus muscle

G. H. Templeton, M. Padalino, J. Manton, M. Glasberg, C. J. Silver, P. Silver, G. DeMartino, T. Leconey, G. Klug, H. Hagler

Research output: Contribution to journalArticle

87 Scopus citations

Abstract

Hindlimb hypokinesia was induced in rats by the Morey method to characterize the response of the soleus muscle. Rats suspended for 1-4 wk exhibited continuous and significant declines in soleus mass, function, and contractile duration. Soleus speeding was in part explained by an alteration in fiber type. The normal incidence of 70-90% type I fibers in the soleus muscle was reduced after 4 wk of suspension to 50% or less in 9 of 11 rats. A significant decline in type I myosin isozyme content occurred without a change in that of type II. Other observed histochemical changes were characteristic of denervation. Consistent with soleus atrophy, there was a significant increase in lysosomal (aci) protease activity. One week of recovery after a 2-wk suspension was characterized by a return to values not significantly different from control for muscle wet weights, peak contraction force, one-half relaxation time, and type I myosin. Persistent differences from control were observed in maximal rate of tension development, contraction time, and denervation-like changes.

Original languageEnglish (US)
Pages (from-to)278-286
Number of pages9
JournalJournal of Applied Physiology Respiratory Environmental and Exercise Physiology
Volume56
Issue number2
DOIs
StatePublished - 1984

ASJC Scopus subject areas

  • Physiology
  • Endocrinology

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