Inhaled albuterol increases estimated ventilatory capacity in nonasthmatic children without and with obesity

Daniel P. Wilhite, Dharini M. Bhammar, Bryce N. Balmain, Tanya Martinez-Fernandez, Tony G. Babb

Research output: Contribution to journalArticlepeer-review

Abstract

Forced mid-expiratory flow (i.e., isoFEF25−75) may increase with a short-acting β2-agonist in nonasthmatic children without bronchodilator responsiveness. This could also increase estimated ventilatory capacity along mid-expiration (V̇Ecap25−75), especially in vulnerable children with obesity who exhibit altered breathing mechanics. We estimated V̇Ecap25−75 pre- and post-albuterol treatment in 8−12yo children without (n = 28) and with (n = 46) obesity. A two-way ANOVA was performed to determine effects of an inhaled bronchodilator (pre-post) and obesity (group) on isoFEF25−75 and V̇Ecap25−75. There was no group by bronchodilator interaction or main group effect on outcome variables. However, a significant main effect of the bronchodilator was detected in spirometry parameters, including a substantial increase in isoFEF25−75 (17.1 ± 18.0 %) and only a slight (non-clinical) but significant increase in FEV1 (2.4 ± 4.3 %). V̇Ecap25−75 significantly increased with albuterol (+11.7 ± 10.6 L/min; +15.8 ± 13.9 %). These findings imply potentially important increases in ventilatory reserve with a bronchodilator in nonasthmatic children without and with obesity, which could potentially influence respiratory function at rest and during exercise.

Original languageEnglish (US)
Article number103597
JournalRespiratory Physiology and Neurobiology
Volume285
DOIs
StatePublished - Mar 2021

Keywords

  • Bronchodilator
  • FEF
  • FEV
  • Forced expiratory flow
  • Responsiveness
  • Spirometry

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology
  • Pulmonary and Respiratory Medicine

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