Inhaled corticosteroid use is associated with lower mortality for subjects with COPD and hospitalised with pneumonia

R. Malo De Molina, E. M. Mortensen, M. I. Restrepo, L. A. Copeland, M. J V Pugh, A. Anzueto

Research output: Contribution to journalArticle

65 Scopus citations

Abstract

Recent studies suggest that use of inhaled corticosteroids (ICS) in chronic obstructive pulmonary disease (COPD) may be associated with a higher incidence of pneumonia. However, it is unclear whether COPD subjects on ICS who develop pneumonia have worse outcomes. Therefore, our aim was to examine the association of prior outpatient ICS therapy with mortality in hospitalised COPD subjects with pneumonia. We included subjects ≥64 yrs of age, hospitalised with pneumonia in US Veterans Affairs hospitals, and assessed the association of ICS exposure with mortality for hospitalised COPD subjects with pneumonia in a covariate-adjusted regression model. We identified 6,353 subjects with a diagnosis of pneumonia and prior COPD, of whom 38% were on ICS. Mortality was 9% at 30 days and 16% at 90 days. In regression analyses, outpatient ICS therapy was associated with lower mortality at both 30 days (OR 0.76, 95% CI 0.70-0.83), and 90 days (OR 0.80, 95% CI 0.75-0.86). Outpatient therapy with ICS was associated with a significantly lower 30- and 90-day mortality in hospitalised COPD patients with pneumonia. Copyright

Original languageEnglish (US)
Pages (from-to)751-757
Number of pages7
JournalEuropean Respiratory Journal
Volume36
Issue number4
DOIs
StatePublished - Oct 1 2010

Keywords

  • Chronic obstructive pulmonary disease
  • Inhaled corticosteroids
  • Mortality
  • Pneumonia

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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