Inhibition by insulin of cardiac cathepsin D activity

Kern Wildenthal

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

IN previous studies of foetal mouse hearts in organ culture, I have demonstrated that insulin improves net protein and amino acid balance 1 and prolongs the duration of survival and beating in vitro 2. The hormone exerts its action on amino acids such as phenylalanine whose metabolic pathways in the heart are confined almost exclusively to protein synthesis and degradation, as well as on those such as valine and alanine that may enter a variety of alternative pathways as well.

Original languageEnglish (US)
Pages (from-to)226-227
Number of pages2
JournalNature
Volume243
Issue number5404
DOIs
StatePublished - Dec 1 1973

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