Abstract
1. The effect of amphetamine on gastrointestinal (GI) transit and the plasma levels of cholecystokinin (CCK) were studied in male rats. 2. Gastric emptying was inhibited both acutely and chronically by the administration of amphetamine. GI transit was decreased by the acute administration of amphetamine but not affected by the chronic administration of amphetamine. 3. Plasma CCK levels were increased dose-dependently by amphetamine. 4. Proglumide, a CCK receptor antagonist, prevented amphetamine-induced inhibition of gastric emptying and the decrease in GI transit in male rats. 5. The selective CCK(A) receptor antagonist, lorglumide, dose-dependently attenuated the amphetamine-induced inhibition of gastric emptying in male rats. In contrast, the selective CCK(B) receptor antagonist, PD 135,158, did not reverse the effect of amphetamine on gastric emptying. 6. Both lorglumide and PD 135,158 reversed the inhibitory effect of amphetamine on GI transit in male rats. 7. These results suggest that amphetamine-induced inhibition of gastric emptying and intestinal transit is due in part to a mechanism associated with the hypersecretion of endogenous CCK.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1123-1130 |
| Number of pages | 8 |
| Journal | British Journal of Pharmacology |
| Volume | 124 |
| Issue number | 6 |
| DOIs | |
| State | Published - 1998 |
Fingerprint
Keywords
- Amphetamine
- Cholecystokinin (CCK)
- Gastric emptying
- Gastrointestinal (GI) transit
- Geometric centre
- Lorglumide
- PD 135,158
- Proglumide
ASJC Scopus subject areas
- Pharmacology
Cite this
Inhibition of gastric emptying and intestinal transit by amphetamine through a mechanism involving an increased secretion of CCK in male rats. / Doong, Ming Luen; Lu, Chien Chen; Kau, Mei Mei; Tsai, Shiow Chwen; Chiao, Yu Chung; Chen, Jiann Jong; Yeh, Jiun Yih; Lin, Ho; Huang, Seng Wong; Chen, Tseng Shing; Chang, Full Young; Wang, Paulus S.
In: British Journal of Pharmacology, Vol. 124, No. 6, 1998, p. 1123-1130.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Inhibition of gastric emptying and intestinal transit by amphetamine through a mechanism involving an increased secretion of CCK in male rats
AU - Doong, Ming Luen
AU - Lu, Chien Chen
AU - Kau, Mei Mei
AU - Tsai, Shiow Chwen
AU - Chiao, Yu Chung
AU - Chen, Jiann Jong
AU - Yeh, Jiun Yih
AU - Lin, Ho
AU - Huang, Seng Wong
AU - Chen, Tseng Shing
AU - Chang, Full Young
AU - Wang, Paulus S.
PY - 1998
Y1 - 1998
N2 - 1. The effect of amphetamine on gastrointestinal (GI) transit and the plasma levels of cholecystokinin (CCK) were studied in male rats. 2. Gastric emptying was inhibited both acutely and chronically by the administration of amphetamine. GI transit was decreased by the acute administration of amphetamine but not affected by the chronic administration of amphetamine. 3. Plasma CCK levels were increased dose-dependently by amphetamine. 4. Proglumide, a CCK receptor antagonist, prevented amphetamine-induced inhibition of gastric emptying and the decrease in GI transit in male rats. 5. The selective CCK(A) receptor antagonist, lorglumide, dose-dependently attenuated the amphetamine-induced inhibition of gastric emptying in male rats. In contrast, the selective CCK(B) receptor antagonist, PD 135,158, did not reverse the effect of amphetamine on gastric emptying. 6. Both lorglumide and PD 135,158 reversed the inhibitory effect of amphetamine on GI transit in male rats. 7. These results suggest that amphetamine-induced inhibition of gastric emptying and intestinal transit is due in part to a mechanism associated with the hypersecretion of endogenous CCK.
AB - 1. The effect of amphetamine on gastrointestinal (GI) transit and the plasma levels of cholecystokinin (CCK) were studied in male rats. 2. Gastric emptying was inhibited both acutely and chronically by the administration of amphetamine. GI transit was decreased by the acute administration of amphetamine but not affected by the chronic administration of amphetamine. 3. Plasma CCK levels were increased dose-dependently by amphetamine. 4. Proglumide, a CCK receptor antagonist, prevented amphetamine-induced inhibition of gastric emptying and the decrease in GI transit in male rats. 5. The selective CCK(A) receptor antagonist, lorglumide, dose-dependently attenuated the amphetamine-induced inhibition of gastric emptying in male rats. In contrast, the selective CCK(B) receptor antagonist, PD 135,158, did not reverse the effect of amphetamine on gastric emptying. 6. Both lorglumide and PD 135,158 reversed the inhibitory effect of amphetamine on GI transit in male rats. 7. These results suggest that amphetamine-induced inhibition of gastric emptying and intestinal transit is due in part to a mechanism associated with the hypersecretion of endogenous CCK.
KW - Amphetamine
KW - Cholecystokinin (CCK)
KW - Gastric emptying
KW - Gastrointestinal (GI) transit
KW - Geometric centre
KW - Lorglumide
KW - PD 135,158
KW - Proglumide
UR - http://www.scopus.com/inward/record.url?scp=14444276529&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=14444276529&partnerID=8YFLogxK
U2 - 10.1038/sj.bjp.0701937
DO - 10.1038/sj.bjp.0701937
M3 - Article
C2 - 9720782
AN - SCOPUS:14444276529
VL - 124
SP - 1123
EP - 1130
JO - British Journal of Pharmacology
JF - British Journal of Pharmacology
SN - 0007-1188
IS - 6
ER -