Inhibitory effects of β-adrenergic agonists on gastric acid secretion in dogs

M. H. Stevens, R. C. Thirlby, C. T. Richardson, M. A. Fredrickson, R. H. Unger, M. Feldman

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

We evaluated the effect of two β-adrenergic agonists, isoproterenol (nonselective agonist) and terbutaline (selective β2-agonist), on gastric acid secretion stimulated by intravenous pentagastrin, bethanechol, or histamine in dogs with gastric fistulas. Intravenous infusion of isoproterenol or terbutaline inhibited pentagastrin-stimulated acid secretion to a significantly greater extent than they inhibited bethanechol- or histamine-stimulated acid secretion. For example, isoproterenol (12 μg.kg-1.h-1) reduced mean pentagastrin-, bethanechol-, and histamine-stimulated acid output by 86, 63, and 14%, respectively. Percent inhibition of acid secretion with terbutaline (30 μg.kg-1.h-1) averaged 60, 17, and 24% for pentagastrin, bethanechol, and histamine, respectively. Terbutaline also inhibited pentagastrin-stimulated acid secretion from vagally denervated fundic pouches in a dose-related manner. Plasma somatostatin-like immunoreactivity was significantly higher during infusion of terbutaline plus pentagastrin than during infusion of pentagastrin alone. However, an intravenous infusion of 0.3 μg.kg-1.h-1 somatostatin-14 had no effect on pentagastrin-stimulated acid secretion from the gastric fistula, even though this infusion increased plasma somatostatin-like immunoreactivity to the same extent as terbutaline plus pentagastrin infusion. Thus the amount of somatostatin released during terbutaline infusion was not sufficient to explain the inhibition of pentagastrin-stimulated acid secretion observed.

Original languageEnglish (US)
Pages (from-to)14/4
JournalAmerican Journal of Physiology - Gastrointestinal and Liver Physiology
Volume251
Issue number4
StatePublished - Dec 1 1986

    Fingerprint

ASJC Scopus subject areas

  • Physiology
  • Hepatology
  • Gastroenterology
  • Physiology (medical)

Cite this

Stevens, M. H., Thirlby, R. C., Richardson, C. T., Fredrickson, M. A., Unger, R. H., & Feldman, M. (1986). Inhibitory effects of β-adrenergic agonists on gastric acid secretion in dogs. American Journal of Physiology - Gastrointestinal and Liver Physiology, 251(4), 14/4.