Initiation of human parturition: VIII. Metabolism of progesterone by fetal membranes of early and late human gestation

L. Milewich, N. F. Gant, B. E. Schwarz, P. C. MacDonald

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

A decreased rate of progesterone metabolism is detected in human fetal membranes several weeks preceding normal parturition at term. A 10- to 20-fold decrease in 20α-hydroxysteroid oxidoreductase activity and a 2- to 6-fold decrease in 5α-reductase activity are observed in human amnion and chorion laeve after 33 weeks' gestation.

Original languageEnglish (US)
Pages (from-to)45-48
Number of pages4
JournalObstetrics and gynecology
Volume50
Issue number1
StatePublished - Jul 1977

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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