Injury-stimulated and self-restrained BMP signaling dynamically regulates stem cell pool size during Drosophila midgut regeneration

Aiguo Tian, Bing Wang, Jin Jiang

Research output: Contribution to journalArticle

Abstract

Many adult organs rely on resident stem cells to maintain homeostasis. Upon injury, stem cells increase proliferation, followed by lineage differentiation to replenish damaged cells. Whether stem cells also change division mode to transiently increase their population size as part of a regenerative program and, if so, what the underlying mechanism is have remained largely unexplored. Here we show that injury stimulates the production of two bone morphogenetic protein (BMP) ligands, Dpp and Gbb, which drive an expansion of intestinal stem cells (ISCs) by promoting their symmetric self-renewing division in Drosophila adult midgut. We find that BMP production in enterocytes is inhibited by BMP signaling itself, and that BMP autoinhibition is required for resetting ISC pool size to the homeostatic level after tissue repair. Our study suggests that dynamic BMP signaling controls ISC population size during midgut regeneration and reveals mechanisms that precisely control stem cell number in response to tissue needs.

Original languageEnglish (US)
Pages (from-to)E2699-E2708
JournalProceedings of the National Academy of Sciences of the United States of America
Volume114
Issue number13
DOIs
StatePublished - Mar 28 2017

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Bone Morphogenetic Proteins
Cell Size
Drosophila
Regeneration
Stem Cells
Wounds and Injuries
Population Density
Enterocytes
Homeostasis
Cell Count
Cell Proliferation
Ligands

Keywords

  • BMP
  • Dpp
  • Midgut
  • Regeneration
  • Stem Cell

ASJC Scopus subject areas

  • General

Cite this

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