Innate immunity SNPs are associated with risk for severe sepsis after burn injury

Robert C. Barber, Ling Yu E Chang, Brett D. Arnoldo, Gary F. Purdue, John L. Hunt, Jureta W. Horton, Corinne C. Aragaki

Research output: Contribution to journalArticle

77 Scopus citations

Abstract

Objective: To analyze allelic association with clinical outcome in a cohort of burn patients. Patients: Two hundred twenty-eight individuals with burns ≥15% total body surface area without significant non-burn related trauma who survived >48 hours post-admission were enrolled. One hundred fifty-nine of these patients were analyzed previously. Methods: Candidate polymorphisms within interleukin-1 beta (IL-1β), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), cellular differentiation marker 14 (CD14) and toll-like receptor 4 (TLR4) were evaluated by logistic regression analysis for association with increased risk for severe sepsis (sepsis plus organ dysfunction or shock). Results: After adjustment for age, burn size, ethnicity, gender and inhalation injury, alleles at TNF-α (308G, p=0.013), TLR4 (+896G, p=0.027), IL-6 (174C, p=0.040) and CD14 (159C, p=0.047) were significantly associated with an increased risk for severe sepsis. Conclusions: Carriage of variant alleles at immune response genes were associated with increased risk for severe sepsis after burn injury.

Original languageEnglish (US)
Pages (from-to)250-255
Number of pages6
JournalClinical Medicine and Research
Volume4
Issue number4
DOIs
StatePublished - Dec 2006

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Keywords

  • Allelic association
  • Burns
  • CD14
  • IL-6
  • Polymorphism
  • SNP
  • Sepsis
  • TLR4
  • TNF-α

ASJC Scopus subject areas

  • Community and Home Care

Cite this

Barber, R. C., Chang, L. Y. E., Arnoldo, B. D., Purdue, G. F., Hunt, J. L., Horton, J. W., & Aragaki, C. C. (2006). Innate immunity SNPs are associated with risk for severe sepsis after burn injury. Clinical Medicine and Research, 4(4), 250-255. https://doi.org/10.3121/cmr.4.4.250