TY - JOUR
T1 - Innate immunity to Toxoplasma gondii infection
AU - Yarovinsky, Felix
N1 - Funding Information:
F.Y. gratefully thanks colleagues and the members of his laboratory for the many discussions that contributed to this manuscript. Work in F.Y.’s laboratory is supported by the US National Institutes of Health (AI085263) and the Burroughs Wellcome Fund.
PY - 2014/2
Y1 - 2014/2
N2 - Toxoplasma gondii is a protozoan parasite of global importance. In the laboratory setting, T. gondii is frequently used as a model pathogen to study mechanisms of T helper 1 (TH1) cell-mediated immunity to intracellular infections. However, recent discoveries have shown that innate type 1 immune responses that involve interferon-γ (IFNγ)-producing natural killer (NK) cells and neutrophils, rather than IFNγ-producing T cells, predetermine host resistance to T. gondii. This Review summarizes the Toll-like receptor (TLR)-dependent mechanisms that are responsible for parasite recognition and for the induction of IFNγ production by NK cells, as well as the emerging data about the TLR-independent mechanisms that lead to the IFNγ-mediated elimination of T. gondii.
AB - Toxoplasma gondii is a protozoan parasite of global importance. In the laboratory setting, T. gondii is frequently used as a model pathogen to study mechanisms of T helper 1 (TH1) cell-mediated immunity to intracellular infections. However, recent discoveries have shown that innate type 1 immune responses that involve interferon-γ (IFNγ)-producing natural killer (NK) cells and neutrophils, rather than IFNγ-producing T cells, predetermine host resistance to T. gondii. This Review summarizes the Toll-like receptor (TLR)-dependent mechanisms that are responsible for parasite recognition and for the induction of IFNγ production by NK cells, as well as the emerging data about the TLR-independent mechanisms that lead to the IFNγ-mediated elimination of T. gondii.
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U2 - 10.1038/nri3598
DO - 10.1038/nri3598
M3 - Review article
C2 - 24457485
AN - SCOPUS:84893115383
SN - 1474-1733
VL - 14
SP - 109
EP - 121
JO - Nature Reviews Immunology
JF - Nature Reviews Immunology
IS - 2
ER -