Insig-dependent ubiquitination and degradation of 3-hydroxy-3- methylglutaryl coenzyme A reductase stimulated by δ- and γ-tocotrienols

Medicine & Life Sciences

• Tocotrienols 100%
• 3-hydroxy-3-methylglutaryl-coenzyme A 83%
• Ubiquitination 69%
• Oxidoreductases 58%
• Sterol Regulatory Element Binding Proteins 41%
• Sterols 32%
• Vitamin E 28%
• Endoplasmic Reticulum-Associated Degradation 13%
• Tocopherols 12%
• Enzymes 10%
• Proteasome Endopeptidase Complex 9%
• Endoplasmic Reticulum 8%
• Membrane Proteins 7%
• Antioxidants 6%
• Cholesterol 6%
• Animals 4%
• In Vitro Techniques 4%

Chemical Compounds

• Coenzyme A 79%
• Vitamin E 57%
• Sterol 52%
• Protein 26%
• Tocotrienol 25%
• Hypocholesterolemic 24%
• Block Like Crystal 21%
• Cholesterol 14%
• Pharmacological Metabolism 12%
• Antioxidant Agent 12%