Insig proteins mediate feedback inhibition of cholesterol synthesis in the intestine

Matthew R. McFarlane, Guosheng Liang, Luke J. Engelking

Research output: Contribution to journalArticle

16 Scopus citations


Background: Insig proteins are required for feedback regulation of cholesterol synthesis in cultured cells and liver. Insig may play a similar role in intestine. Results: Insig deficiency in enterocytes leads to constitutively elevated cholesterol synthesis in intestine. Conclusion: Intestinal regulation of cholesterol homeostasis requires Insig. Significance: This work provides insight into how enterocytes coordinately balance de novo cholesterol synthesis and absorption.

Original languageEnglish (US)
Pages (from-to)2148-2156
Number of pages9
JournalJournal of Biological Chemistry
Issue number4
Publication statusPublished - Jan 24 2014


ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

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