Insig proteins mediate feedback inhibition of cholesterol synthesis in the intestine

Matthew R. McFarlane, Guosheng Liang, Luke J. Engelking

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Background: Insig proteins are required for feedback regulation of cholesterol synthesis in cultured cells and liver. Insig may play a similar role in intestine. Results: Insig deficiency in enterocytes leads to constitutively elevated cholesterol synthesis in intestine. Conclusion: Intestinal regulation of cholesterol homeostasis requires Insig. Significance: This work provides insight into how enterocytes coordinately balance de novo cholesterol synthesis and absorption.

Original languageEnglish (US)
Pages (from-to)2148-2156
Number of pages9
JournalJournal of Biological Chemistry
Volume289
Issue number4
DOIs
StatePublished - Jan 24 2014

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Intestines
Enterocytes
Cholesterol
Feedback
Proteins
Hypercholesterolemia
Cultured Cells
Homeostasis
Liver
Cells

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

Insig proteins mediate feedback inhibition of cholesterol synthesis in the intestine. / McFarlane, Matthew R.; Liang, Guosheng; Engelking, Luke J.

In: Journal of Biological Chemistry, Vol. 289, No. 4, 24.01.2014, p. 2148-2156.

Research output: Contribution to journalArticle

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