Interaction of carotid chemoreceptor and pulmonary inflation reflexes in circulatory regulation in conscious dogs

S. F. Vatner, J. D. Rutherford

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

The interaction of carotid chemoreceptor and pulmonary inflation reflex control of peripheral and coronary vasoactivity and myocardial contractility was examined in conscious dogs. Stimulation of carotid chemoreceptors resulted in an increase in rate and depth of respiration, an increase in myocadial contractility, and more intense vasoconstriction in the iliac than in the mesenteric, renal, or cerebral beds. The coronary bed responded primarily with vasodilation. The increase in rate and depth of respiration stimulated pulmonary inflation reflexes, which in turn were partially responsible for the coronary vasodilation, but also attenuated the positive inotropic response and even reversed the initial peripheral vasoconstriction to a period of significant vasodilation.

Original languageEnglish (US)
Pages (from-to)2188-2193
Number of pages6
JournalFederation Proceedings
Volume40
Issue number8
StatePublished - Dec 1 1981

ASJC Scopus subject areas

  • Medicine(all)

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