Interaction of diet and genes in atherogenesis report of an NHLBI Working Group

A. Tall, C. Welch, D. Applebaum-Bowden, M. Wassef, J. M. Dietschy, Scott M Grundy, A. J. Lusis, P. R. McPherson, T. F. Osborne, L. L. Rudel, E. J. Schaefer, M. Wassef, D. Applehaum-Bowden, A. Ershow

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Recent advances in genetics and information emerging from the Human Genome Project make it feasible to examine the importance of dietary-genetic interactions in the development of atherosclerosiS. In the opinion of the Working Group, three approaches are necessary to examine this concern. The first approach utilizes animal models to map and identify candidate genes involved in dietary responsiveness and atherogenesis. The second approach involves the evaluation of these genes in specific physiological processes involved in dietary responsiveness and atherogenesis. Finally, the third approach is to extend the studies performed in animal models to human populations using linkage or association studies.

Original languageEnglish (US)
Pages (from-to)3326-3331
Number of pages6
JournalArteriosclerosis, thrombosis, and vascular biology
Volume17
Issue number11
DOIs
StatePublished - Jan 1 1997

Keywords

  • Atherogenesis
  • Diet
  • Genes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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