Interactions Between Toxoplasma Effectors and Host Immune Responses

Barbara A. Butcher, Michael L. Reese, John C. Boothroyd, Eric Y. Denkers

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Abstract

As an intracellular parasite, Toxoplasma gondii must avoid a variety of host defences including the host immune response. Recent studies have demonstrated that T. gondii extensively remodels its host altering host metabolism and gene expression. These events are mediated by parasite products that are secreted into the host cell during and after invasion. This chapter discusses the identification and mechanism of action of the rhoptry and dense granule proteins that alter host cell signalling and immune response.

Original languageEnglish (US)
Title of host publicationToxoplasma Gondii
Subtitle of host publicationThe Model Apicomplexan - Perspectives and Methods: Second Edition
PublisherElsevier Ltd
Pages505-519
Number of pages15
ISBN (Print)9780123964816
DOIs
StatePublished - Sep 1 2013

Keywords

  • Macrophage
  • Pseudokinase
  • ROP kinase
  • Rhoptry

ASJC Scopus subject areas

  • Immunology and Microbiology(all)

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  • Cite this

    Butcher, B. A., Reese, M. L., Boothroyd, J. C., & Denkers, E. Y. (2013). Interactions Between Toxoplasma Effectors and Host Immune Responses. In Toxoplasma Gondii: The Model Apicomplexan - Perspectives and Methods: Second Edition (pp. 505-519). Elsevier Ltd. https://doi.org/10.1016/B978-0-12-396481-6.00014-3