Interleukin-2 does not induce murine B cells to secrete Ig

E. Pure, P. C. Isakson, V. Paetkau, B. Caplan, E. S. Vitetta, P. H. Krammer

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Abstract

We previously defined two T cell-derived lymphokines, BDCF(μ) and BCDF(γ), which induce B cell differentiation in the absence of IL 2. Although these studies indicated that IL 2 was not required to induce Ig secretion, the effect of IL 2 on B cell differentiation was not established. In the present studies we have assessed the ability of purified IL 2 to induce IgM or IgG secretion. Our results demonstrate that IL 2 does not induce IgG secretion by BCL 1 tumor cells, nor does it enhance BCDF(μ)-induced IgM secretion by these cells. Similarly, IL 2 had no effect on LPS or BCDF(γ)-induced IgG secretion by normal B cells. Thus, we conclude that IL 2 does not act directly on B cells to induce differentiation.

Original languageEnglish (US)
Pages (from-to)2420-2425
Number of pages6
JournalJournal of Immunology
Volume129
Issue number6
Publication statusPublished - 1982

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ASJC Scopus subject areas

  • Immunology

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Pure, E., Isakson, P. C., Paetkau, V., Caplan, B., Vitetta, E. S., & Krammer, P. H. (1982). Interleukin-2 does not induce murine B cells to secrete Ig. Journal of Immunology, 129(6), 2420-2425.