Interleukin-2 does not induce murine B cells to secrete Ig

We previously defined two T cell-derived lymphokines, BDCF(μ) and BCDF(γ), which induce B cell differentiation in the absence of IL 2. Although these studies indicated that IL 2 was not required to induce Ig secretion, the effect of IL 2 on B cell differentiation was not established. In the present studies we have assessed the ability of purified IL 2 to induce IgM or IgG secretion. Our results demonstrate that IL 2 does not induce IgG secretion by BCL ₁ tumor cells, nor does it enhance BCDF(μ)-induced IgM secretion by these cells. Similarly, IL 2 had no effect on LPS or BCDF(γ)-induced IgG secretion by normal B cells. Thus, we conclude that IL 2 does not act directly on B cells to induce differentiation.