Interleukin-2 does not induce murine B cells to secrete Ig

E. Pure, P. C. Isakson, V. Paetkau, B. Caplan, E. S. Vitetta, P. H. Krammer

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Abstract

We previously defined two T cell-derived lymphokines, BDCF(μ) and BCDF(γ), which induce B cell differentiation in the absence of IL 2. Although these studies indicated that IL 2 was not required to induce Ig secretion, the effect of IL 2 on B cell differentiation was not established. In the present studies we have assessed the ability of purified IL 2 to induce IgM or IgG secretion. Our results demonstrate that IL 2 does not induce IgG secretion by BCL 1 tumor cells, nor does it enhance BCDF(μ)-induced IgM secretion by these cells. Similarly, IL 2 had no effect on LPS or BCDF(γ)-induced IgG secretion by normal B cells. Thus, we conclude that IL 2 does not act directly on B cells to induce differentiation.

Original languageEnglish (US)
Pages (from-to)2420-2425
Number of pages6
JournalJournal of Immunology
Volume129
Issue number6
StatePublished - 1982

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Interleukin-2
B-Lymphocytes
Immunoglobulin G
Immunoglobulin M
Cell Differentiation
Lymphokines
T-Lymphocytes
Neoplasms

ASJC Scopus subject areas

  • Immunology

Cite this

Pure, E., Isakson, P. C., Paetkau, V., Caplan, B., Vitetta, E. S., & Krammer, P. H. (1982). Interleukin-2 does not induce murine B cells to secrete Ig. Journal of Immunology, 129(6), 2420-2425.

Interleukin-2 does not induce murine B cells to secrete Ig. / Pure, E.; Isakson, P. C.; Paetkau, V.; Caplan, B.; Vitetta, E. S.; Krammer, P. H.

In: Journal of Immunology, Vol. 129, No. 6, 1982, p. 2420-2425.

Research output: Contribution to journalArticle

Pure, E, Isakson, PC, Paetkau, V, Caplan, B, Vitetta, ES & Krammer, PH 1982, 'Interleukin-2 does not induce murine B cells to secrete Ig', Journal of Immunology, vol. 129, no. 6, pp. 2420-2425.
Pure E, Isakson PC, Paetkau V, Caplan B, Vitetta ES, Krammer PH. Interleukin-2 does not induce murine B cells to secrete Ig. Journal of Immunology. 1982;129(6):2420-2425.
Pure, E. ; Isakson, P. C. ; Paetkau, V. ; Caplan, B. ; Vitetta, E. S. ; Krammer, P. H. / Interleukin-2 does not induce murine B cells to secrete Ig. In: Journal of Immunology. 1982 ; Vol. 129, No. 6. pp. 2420-2425.
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