Interleukin-33/ST2 system attenuates aldosterone-induced adipogenesis and inflammation

Ernesto Martínez-Martínez, Victoria Cachofeiro, Elodie Rousseau, Virginia Álvarez, Laurent Calvier, Amaya Fernández-Celis, Céline Leroy, María Miana, Raquel Jurado-López, Ana M. Briones, Frederic Jaisser, Faiez Zannad, Patrick Rossignol, Natalia López-Andrés

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Interleukin-33 (IL-33) but not soluble ST2 (sST2) exerts anti-inflammatory and protective effects in several tissues. Aldosterone, a proinflammatory mediator which promotes adipogenesis, is elevated in obese patients. The aim of this study was to investigate the interactions between IL-33/ST2 system and Aldosterone in adipose tissue. Rats fed a high fat diet presented increased sST2 expression, diminished IL-33/sST2 ratio and enhanced levels of differentiation and inflammation in adipose tissue as compared to controls. A similar pattern was observed in adipose tissue from C57BL/6 Aldosterone-treated mice. In both animal models, Aldosterone was correlated with sST2. Treatment of 3T3-L1 adipocytes with IL-33 delayed adipocyte differentiation diminished lipid accumulation and decreased inflammation. Aldosterone decreased IL-33 and increased sST2 expressions in differentiated adipocytes. Aldosterone-induced adipocyte differentiation and inflammation were blocked by IL-33 treatment, but sST2 did not exert any effects. The crosstalk between IL-33/ST2 and Aldosterone could be relevant in the metabolic consequences of obesity.

Original languageEnglish (US)
Pages (from-to)20-27
Number of pages8
JournalMolecular and Cellular Endocrinology
Volume411
DOIs
StatePublished - Aug 5 2015
Externally publishedYes

Fingerprint

Adipogenesis
Aldosterone
Inflammation
Adipocytes
Tissue
Adipose Tissue
High Fat Diet
Nutrition
Crosstalk
Interleukin-33
Rats
Animals
Anti-Inflammatory Agents
Animal Models
Obesity
Fats
Lipids
Therapeutics

Keywords

  • Adipocyte differentiation
  • Adipose tissue
  • Aldosterone
  • IL-33/ST2 system

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Endocrinology

Cite this

Martínez-Martínez, E., Cachofeiro, V., Rousseau, E., Álvarez, V., Calvier, L., Fernández-Celis, A., ... López-Andrés, N. (2015). Interleukin-33/ST2 system attenuates aldosterone-induced adipogenesis and inflammation. Molecular and Cellular Endocrinology, 411, 20-27. https://doi.org/10.1016/j.mce.2015.04.007

Interleukin-33/ST2 system attenuates aldosterone-induced adipogenesis and inflammation. / Martínez-Martínez, Ernesto; Cachofeiro, Victoria; Rousseau, Elodie; Álvarez, Virginia; Calvier, Laurent; Fernández-Celis, Amaya; Leroy, Céline; Miana, María; Jurado-López, Raquel; Briones, Ana M.; Jaisser, Frederic; Zannad, Faiez; Rossignol, Patrick; López-Andrés, Natalia.

In: Molecular and Cellular Endocrinology, Vol. 411, 05.08.2015, p. 20-27.

Research output: Contribution to journalArticle

Martínez-Martínez, E, Cachofeiro, V, Rousseau, E, Álvarez, V, Calvier, L, Fernández-Celis, A, Leroy, C, Miana, M, Jurado-López, R, Briones, AM, Jaisser, F, Zannad, F, Rossignol, P & López-Andrés, N 2015, 'Interleukin-33/ST2 system attenuates aldosterone-induced adipogenesis and inflammation', Molecular and Cellular Endocrinology, vol. 411, pp. 20-27. https://doi.org/10.1016/j.mce.2015.04.007
Martínez-Martínez, Ernesto ; Cachofeiro, Victoria ; Rousseau, Elodie ; Álvarez, Virginia ; Calvier, Laurent ; Fernández-Celis, Amaya ; Leroy, Céline ; Miana, María ; Jurado-López, Raquel ; Briones, Ana M. ; Jaisser, Frederic ; Zannad, Faiez ; Rossignol, Patrick ; López-Andrés, Natalia. / Interleukin-33/ST2 system attenuates aldosterone-induced adipogenesis and inflammation. In: Molecular and Cellular Endocrinology. 2015 ; Vol. 411. pp. 20-27.
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