TY - JOUR
T1 - Interleukin-33/ST2 system attenuates aldosterone-induced adipogenesis and inflammation
AU - Martínez-Martínez, Ernesto
AU - Cachofeiro, Victoria
AU - Rousseau, Elodie
AU - Álvarez, Virginia
AU - Calvier, Laurent
AU - Fernández-Celis, Amaya
AU - Leroy, Céline
AU - Miana, María
AU - Jurado-López, Raquel
AU - Briones, Ana M.
AU - Jaisser, Frederic
AU - Zannad, Faiez
AU - Rossignol, Patrick
AU - López-Andrés, Natalia
N1 - Funding Information:
This work was supported by grants from INSERM , Programme National de Recherche Cardiovasculaire , Région Lorraine , Fondo de Investigaciones Sanitarias ( PI12/01729 ), Red de Investigación Cardiovascular ( RD12/0042/0033 ), Miguel Servet Programme ( CP13/00221 ). Ernesto Martínez-Martínez, Victoria Cachofeiro, María Miana, Raquel Jurado-López, Natalia López-Andrés, and Ana M. Briones are members of the Red de Investigación Cardiovascular (RIC) [ RD12/0042/0033 and RD12/0042/0024 ].
Publisher Copyright:
© 2015 Elsevier Ireland Ltd.
PY - 2015/8/5
Y1 - 2015/8/5
N2 - Interleukin-33 (IL-33) but not soluble ST2 (sST2) exerts anti-inflammatory and protective effects in several tissues. Aldosterone, a proinflammatory mediator which promotes adipogenesis, is elevated in obese patients. The aim of this study was to investigate the interactions between IL-33/ST2 system and Aldosterone in adipose tissue. Rats fed a high fat diet presented increased sST2 expression, diminished IL-33/sST2 ratio and enhanced levels of differentiation and inflammation in adipose tissue as compared to controls. A similar pattern was observed in adipose tissue from C57BL/6 Aldosterone-treated mice. In both animal models, Aldosterone was correlated with sST2. Treatment of 3T3-L1 adipocytes with IL-33 delayed adipocyte differentiation diminished lipid accumulation and decreased inflammation. Aldosterone decreased IL-33 and increased sST2 expressions in differentiated adipocytes. Aldosterone-induced adipocyte differentiation and inflammation were blocked by IL-33 treatment, but sST2 did not exert any effects. The crosstalk between IL-33/ST2 and Aldosterone could be relevant in the metabolic consequences of obesity.
AB - Interleukin-33 (IL-33) but not soluble ST2 (sST2) exerts anti-inflammatory and protective effects in several tissues. Aldosterone, a proinflammatory mediator which promotes adipogenesis, is elevated in obese patients. The aim of this study was to investigate the interactions between IL-33/ST2 system and Aldosterone in adipose tissue. Rats fed a high fat diet presented increased sST2 expression, diminished IL-33/sST2 ratio and enhanced levels of differentiation and inflammation in adipose tissue as compared to controls. A similar pattern was observed in adipose tissue from C57BL/6 Aldosterone-treated mice. In both animal models, Aldosterone was correlated with sST2. Treatment of 3T3-L1 adipocytes with IL-33 delayed adipocyte differentiation diminished lipid accumulation and decreased inflammation. Aldosterone decreased IL-33 and increased sST2 expressions in differentiated adipocytes. Aldosterone-induced adipocyte differentiation and inflammation were blocked by IL-33 treatment, but sST2 did not exert any effects. The crosstalk between IL-33/ST2 and Aldosterone could be relevant in the metabolic consequences of obesity.
KW - Adipocyte differentiation
KW - Adipose tissue
KW - Aldosterone
KW - IL-33/ST2 system
UR - http://www.scopus.com/inward/record.url?scp=84930181376&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84930181376&partnerID=8YFLogxK
U2 - 10.1016/j.mce.2015.04.007
DO - 10.1016/j.mce.2015.04.007
M3 - Article
C2 - 25896545
AN - SCOPUS:84930181376
SN - 0303-7207
VL - 411
SP - 20
EP - 27
JO - Molecular and Cellular Endocrinology
JF - Molecular and Cellular Endocrinology
ER -