Interneuronal exchange and functional integration of synaptobrevin via extracellular vesicles

A. Alejandro Vilcaes, Natali L. Chanaday, Ege T Kavalali

Research output: Contribution to journalArticlepeer-review

Abstract

Vilcaes et al. uncover a novel form of interneuronal communication using extracellular vesicles that allows the exchange of synaptic vesicle proteins, including synaptobrevin, via a CD81-dependent mechanism. Through this mechanism, neurons can modify the protein composition and signaling properties of other neurons.

Original languageEnglish (US)
Pages (from-to)971-983.e5
JournalNeuron
Volume109
Issue number6
DOIs
StatePublished - Mar 17 2021
Externally publishedYes

Keywords

  • CD81
  • extracellular vesicles
  • neurotransmission
  • synaptic vesicle
  • synaptobrevin-2

ASJC Scopus subject areas

  • Neuroscience(all)

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