@article{11c6307198ab4370bead41a5d892910c,
title = "Interneuronal exchange and functional integration of synaptobrevin via extracellular vesicles",
abstract = "Vilcaes et al. uncover a novel form of interneuronal communication using extracellular vesicles that allows the exchange of synaptic vesicle proteins, including synaptobrevin, via a CD81-dependent mechanism. Through this mechanism, neurons can modify the protein composition and signaling properties of other neurons.",
keywords = "CD81, extracellular vesicles, neurotransmission, synaptic vesicle, synaptobrevin-2",
author = "Vilcaes, {A. Alejandro} and Chanaday, {Natali L.} and Kavalali, {Ege T.}",
note = "Funding Information: We would like to thank Dr. Hamid Mirzaei (UT Southwestern) for his help in performing and analyzing the proteomics experiment. We are grateful to Dr. Evan Krystofiak from the Research Electron Microscropy Resource (Vanderbilt University) and Dr. Dmitry S. Koktysh from VINSE Nanocrystal/Analytical Laboratory (Vanderbilt University) for their assistance. We are grateful to Dr. Alissa Weaver for generously providing the CD63-pHluorin construct. We also thank Drs. Lisa Monteggia, Helmut Kramer, Alissa Weaver, and Qiangjun Zhou for their insightful comments on the manuscript. This work was supported by a grant from the National Institute of Mental Health (MH066198) to E.T.K. a research fellowship from the Scientific and Technical Research National Council of Argentina (CONICET) to A.A.V. and a NARSAD young investigator award to N.L.C. Conceptualization, N.L.C. A.A.V. and E.T.K.; Methodology, Investigation, and Formal Analysis, N.L.C. and A.A.V.; Interpretation, Discussion, Writing, and Editing, N.L.C. A.A.V. and E.T.K.; Funding Acquisition and Resources, E.T.K. and N.L.C. The authors declare no competing interests. Funding Information: We would like to thank Dr. Hamid Mirzaei (UT Southwestern) for his help in performing and analyzing the proteomics experiment. We are grateful to Dr. Evan Krystofiak from the Research Electron Microscropy Resource (Vanderbilt University) and Dr. Dmitry S. Koktysh from VINSE Nanocrystal/Analytical Laboratory (Vanderbilt University) for their assistance. We are grateful to Dr. Alissa Weaver for generously providing the CD63-pHluorin construct. We also thank Drs. Lisa Monteggia, Helmut Kramer, Alissa Weaver, and Qiangjun Zhou for their insightful comments on the manuscript. This work was supported by a grant from the National Institute of Mental Health ( MH066198 ) to E.T.K., a research fellowship from the Scientific and Technical Research National Council of Argentina (CONICET) to A.A.V., and a NARSAD young investigator award to N.L.C. Publisher Copyright: {\textcopyright} 2021 Elsevier Inc.",
year = "2021",
month = mar,
day = "17",
doi = "10.1016/j.neuron.2021.01.007",
language = "English (US)",
volume = "109",
pages = "971--983.e5",
journal = "Neuron",
issn = "0896-6273",
publisher = "Cell Press",
number = "6",
}