Interplay between Cdh1 and JNK activity during the cell cycle

Gustavo J. Gutierrez; Toshiya Tsuji; Meifan Chen; Wei Jiang; Ze'Ev A. Ronai

doi:10.1038/ncb2071

Interplay between Cdh1 and JNK activity during the cell cycle

Gustavo J. Gutierrez, Toshiya Tsuji, Meifan Chen, Wei Jiang, Ze'Ev A. Ronai

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

The ubiquitin ligase APC/C^Cdh1 coordinates degradation of key cell cycle regulators. We report here that a nuclear-localized portion of the stress-activated kinase JNK is degraded by the APC/C^Cdh1 during exit from mitosis and the G1 phase of the cell cycle. Expression of a non-degradable JNK induces prometaphase-like arrest and aberrant mitotic spindle dynamics. Moreover, JNK phosphorylates Cdh1 directly, during G2 and early mitosis, changing its subcellular localization and attenuating its ability to activate the APC/C during G2/M. This regulatory mechanism between JNK and Cdh1 reveals an important function for JNK during the cell cycle.

Original language	English (US)
Pages (from-to)	686-695
Number of pages	10
Journal	Nature cell biology
Volume	12
Issue number	7
DOIs	https://doi.org/10.1038/ncb2071
State	Published - Jul 2010

ASJC Scopus subject areas

Cell Biology

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title = "Interplay between Cdh1 and JNK activity during the cell cycle",

abstract = "The ubiquitin ligase APC/CCdh1 coordinates degradation of key cell cycle regulators. We report here that a nuclear-localized portion of the stress-activated kinase JNK is degraded by the APC/CCdh1 during exit from mitosis and the G1 phase of the cell cycle. Expression of a non-degradable JNK induces prometaphase-like arrest and aberrant mitotic spindle dynamics. Moreover, JNK phosphorylates Cdh1 directly, during G2 and early mitosis, changing its subcellular localization and attenuating its ability to activate the APC/C during G2/M. This regulatory mechanism between JNK and Cdh1 reveals an important function for JNK during the cell cycle.",

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AU - Ronai, Ze'Ev A.

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AB - The ubiquitin ligase APC/CCdh1 coordinates degradation of key cell cycle regulators. We report here that a nuclear-localized portion of the stress-activated kinase JNK is degraded by the APC/CCdh1 during exit from mitosis and the G1 phase of the cell cycle. Expression of a non-degradable JNK induces prometaphase-like arrest and aberrant mitotic spindle dynamics. Moreover, JNK phosphorylates Cdh1 directly, during G2 and early mitosis, changing its subcellular localization and attenuating its ability to activate the APC/C during G2/M. This regulatory mechanism between JNK and Cdh1 reveals an important function for JNK during the cell cycle.

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Interplay between Cdh1 and JNK activity during the cell cycle

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