Intra-abdominal Fat Predicts Survival in Pancreatic Cancer

Courtney J. Balentine, Jose Enriquez, William Fisher, Sally Hodges, Vivek Bansal, Shubhada Sansgiry, Nancy J. Petersen, David H. Berger

Research output: Contribution to journalArticle

53 Scopus citations

Abstract

Background: Body mass index (BMI) has proven unreliable in predicting survival following pancreaticoduodenectomy for cancer. While measures of intra-abdominal fat correlate with medical and postoperative complications of obesity, the impact of intra-abdominal fat on pancreatic cancer survival is uncertain. We hypothesized that the quantity of intra-abdominal fat would predict survival following resection of pancreatic cancer. Methods: Preoperative CT imaging was used to measure intra-abdominal fat. Cox regression analyses were used to identify independent predictors of survival. Results: Sixty-one patients from 2000-2009 underwent pancreaticoduodenectomy for exocrine pancreatic adenocarcinoma. After adjusting for age and perineural invasion status, preoperative BMI did not predict overall survival (p < 0.827). Unlike BMI, quartile of intra-abdominal fat predicted survival. Relative to patients with the least intra-abdominal fat (lowest quartile), those with more intra-abdominal fat demonstrated worse overall survival, but in a non-linear fashion. Individuals in the second quartile showed a fourfold increase in likelihood of death (HR 4.018, 95% CI 1.099-14.687, p < 0.035) relative to the lowest quartile. Patients in the third (HR 2.124, 95% CI 0.278-16.222, p < 0.468) and fourth quartile (HR 1.354, 95% CI 0.296-6. 190, p < 0.696) also showed greater risk of death. Conclusions: Measuring intra-abdominal fat identifies a subset of patients with worse prognosis in pancreatic cancer.

Original languageEnglish (US)
Pages (from-to)1832-1837
Number of pages6
JournalJournal of Gastrointestinal Surgery
Volume14
Issue number11
DOIs
StatePublished - Aug 20 2010
Externally publishedYes

Keywords

  • Obesity
  • Pancreaticoduodenectomy
  • Survival

ASJC Scopus subject areas

  • Surgery
  • Gastroenterology

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  • Cite this

    Balentine, C. J., Enriquez, J., Fisher, W., Hodges, S., Bansal, V., Sansgiry, S., Petersen, N. J., & Berger, D. H. (2010). Intra-abdominal Fat Predicts Survival in Pancreatic Cancer. Journal of Gastrointestinal Surgery, 14(11), 1832-1837. https://doi.org/10.1007/s11605-010-1297-5