Intra-operative hydroxyethyl starch is not associated with post-craniotomy hemorrhage

James A. Feix, C. Andrew Peery, Tong J. Gan, David S. Warner, Michael L. James, Ali Zomorodi, David L. McDonagh

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Background: Intraoperative intravascular volume expansion with hydroxyethyl starch-based colloids is thought to be associated with an increased risk of post-craniotomy hemorrhage. Evidence for this association is limited. Associations between resuscitation with hydroxyethyl starch and risk of repeat craniotomy for hematoma evacuation were examined. Methods: Using a retrospective cohort of neurosurgical patients at Duke University Medical Center between March 2005 and March 2012, patient characteristics were compared between those who developed post-craniotomy hemorrhage and those who did not. Results: A total of 4,109 craniotomy procedures were analyzed with 61 patients having repeat craniotomy for post-operative hemorrhage (1.5%). The rate of reoperation in the group receiving 6% High Molecular Weight Hydroxyethyl Starch (Hextend®) was 2.6 vs. 1.3% for patients that did not receive hetastarch (P = 0.13). The reoperation rate for those receiving 6% hydroxyethyl Starch 130/0.4 (Voluven®) was 1.4 vs. 1.6% in patients not receiving Voluven (P = 0.85). Conclusions: In this retrospective cohort, intra-operative hydroxyethyl starch was not associated with an increased risk of post-craniotomy hemorrhage.

Original languageEnglish (US)
Article number350
JournalSpringerPlus
Volume4
Issue number1
DOIs
StatePublished - Dec 26 2015

Keywords

  • Colloid
  • Craniotomy
  • Hemorrhage
  • Hydroxyethyl starch
  • Neuroanesthesia
  • Neurosurgery

ASJC Scopus subject areas

  • General

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    Feix, J. A., Peery, C. A., Gan, T. J., Warner, D. S., James, M. L., Zomorodi, A., & McDonagh, D. L. (2015). Intra-operative hydroxyethyl starch is not associated with post-craniotomy hemorrhage. SpringerPlus, 4(1), [350]. https://doi.org/10.1186/s40064-015-1126-0