Intraoperative detection of early microvasospasm in patients with subarachnoid hemorrhage by using orthogonal polarization spectral imaging

Eberhard Uhl, Jens Lehmberg, Hans Jakob Steiger, Konrad Messmer, Robert J. Dempsey, Philip E. Stieg, H. Hunt Batjer, Ralf Steinmeier, Gabriele Schackert, Robert A. Solomon

Research output: Contribution to journalArticle

113 Citations (Scopus)

Abstract

OBJECTIVE: Changes of major cerebral vessels in patients with subarachnoid hemorrhage (SAH) are well known from routine cerebral angiography. Data on changes in the microcirculation do not exist. This study sought to provide a qualitative and quantitative analysis of the cortical microcirculation after SAH. METHODS: By means of orthogonal polarization spectral imaging, a qualitative and quantitative analysis of cortical microcirculation was performed during aneurysm surgery in 3 patients with an incidental intracerebral aneurysm and 10 patients with SAH. Vessel diameters, red blood cell velocity, and functional capillary density were analyzed before and after the aneurysm was clipped. RESULTS: Initial capillary density in patients with an incidental aneurysm was 91.5 ± 36.5 cm-1 (mean ± standard deviation) compared with 30.5 ± 13.8 in patients with SAH (P < 0.05). In patients with SAH, capillary density increased significantly to 53.9 ± 29.1 cm-1 (P < 0.05) during the operation, as did the frequency of venules with a red blood cell velocity greater than 2 mm/s (P < 0.05). No significant change of arteriolar or venular diameters was observed. However, in patients with SAH, mono- and multisegmental microvasospasms in arterioles were observed, with a reduction of vessel diameters up to 75.1%. CONCLUSION: Orthogonal polarization spectral imaging is a suitable method to study cerebral microcirculation during surgery. In patients with SAH, capillary density is significantly decreased and small arteries and arterioles of the cortical surface exhibit vasospasm that cannot be detected by angiography or transcranial Doppler sonography. These changes may contribute to the initial clinical symptoms and may have an influence on the clinical postoperative course.

Original languageEnglish (US)
Pages (from-to)1307-1317
Number of pages11
JournalNeurosurgery
Volume52
Issue number6
StatePublished - Jun 1 2003

Fingerprint

Subarachnoid Hemorrhage
Microcirculation
Aneurysm
Arterioles
Erythrocytes
Doppler Transcranial Ultrasonography
Cerebral Angiography
Venules
Angiography
Arteries

Keywords

  • Aneurysm surgery
  • Cerebral microcirculation
  • Orthogonal polarization
  • Spectral imaging
  • Subarachnoid hemorrhage
  • Vasospasm

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

Uhl, E., Lehmberg, J., Steiger, H. J., Messmer, K., Dempsey, R. J., Stieg, P. E., ... Solomon, R. A. (2003). Intraoperative detection of early microvasospasm in patients with subarachnoid hemorrhage by using orthogonal polarization spectral imaging. Neurosurgery, 52(6), 1307-1317.

Intraoperative detection of early microvasospasm in patients with subarachnoid hemorrhage by using orthogonal polarization spectral imaging. / Uhl, Eberhard; Lehmberg, Jens; Steiger, Hans Jakob; Messmer, Konrad; Dempsey, Robert J.; Stieg, Philip E.; Batjer, H. Hunt; Steinmeier, Ralf; Schackert, Gabriele; Solomon, Robert A.

In: Neurosurgery, Vol. 52, No. 6, 01.06.2003, p. 1307-1317.

Research output: Contribution to journalArticle

Uhl, E, Lehmberg, J, Steiger, HJ, Messmer, K, Dempsey, RJ, Stieg, PE, Batjer, HH, Steinmeier, R, Schackert, G & Solomon, RA 2003, 'Intraoperative detection of early microvasospasm in patients with subarachnoid hemorrhage by using orthogonal polarization spectral imaging', Neurosurgery, vol. 52, no. 6, pp. 1307-1317.
Uhl E, Lehmberg J, Steiger HJ, Messmer K, Dempsey RJ, Stieg PE et al. Intraoperative detection of early microvasospasm in patients with subarachnoid hemorrhage by using orthogonal polarization spectral imaging. Neurosurgery. 2003 Jun 1;52(6):1307-1317.
Uhl, Eberhard ; Lehmberg, Jens ; Steiger, Hans Jakob ; Messmer, Konrad ; Dempsey, Robert J. ; Stieg, Philip E. ; Batjer, H. Hunt ; Steinmeier, Ralf ; Schackert, Gabriele ; Solomon, Robert A. / Intraoperative detection of early microvasospasm in patients with subarachnoid hemorrhage by using orthogonal polarization spectral imaging. In: Neurosurgery. 2003 ; Vol. 52, No. 6. pp. 1307-1317.
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abstract = "OBJECTIVE: Changes of major cerebral vessels in patients with subarachnoid hemorrhage (SAH) are well known from routine cerebral angiography. Data on changes in the microcirculation do not exist. This study sought to provide a qualitative and quantitative analysis of the cortical microcirculation after SAH. METHODS: By means of orthogonal polarization spectral imaging, a qualitative and quantitative analysis of cortical microcirculation was performed during aneurysm surgery in 3 patients with an incidental intracerebral aneurysm and 10 patients with SAH. Vessel diameters, red blood cell velocity, and functional capillary density were analyzed before and after the aneurysm was clipped. RESULTS: Initial capillary density in patients with an incidental aneurysm was 91.5 ± 36.5 cm-1 (mean ± standard deviation) compared with 30.5 ± 13.8 in patients with SAH (P < 0.05). In patients with SAH, capillary density increased significantly to 53.9 ± 29.1 cm-1 (P < 0.05) during the operation, as did the frequency of venules with a red blood cell velocity greater than 2 mm/s (P < 0.05). No significant change of arteriolar or venular diameters was observed. However, in patients with SAH, mono- and multisegmental microvasospasms in arterioles were observed, with a reduction of vessel diameters up to 75.1{\%}. CONCLUSION: Orthogonal polarization spectral imaging is a suitable method to study cerebral microcirculation during surgery. In patients with SAH, capillary density is significantly decreased and small arteries and arterioles of the cortical surface exhibit vasospasm that cannot be detected by angiography or transcranial Doppler sonography. These changes may contribute to the initial clinical symptoms and may have an influence on the clinical postoperative course.",
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AU - Uhl, Eberhard

AU - Lehmberg, Jens

AU - Steiger, Hans Jakob

AU - Messmer, Konrad

AU - Dempsey, Robert J.

AU - Stieg, Philip E.

AU - Batjer, H. Hunt

AU - Steinmeier, Ralf

AU - Schackert, Gabriele

AU - Solomon, Robert A.

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N2 - OBJECTIVE: Changes of major cerebral vessels in patients with subarachnoid hemorrhage (SAH) are well known from routine cerebral angiography. Data on changes in the microcirculation do not exist. This study sought to provide a qualitative and quantitative analysis of the cortical microcirculation after SAH. METHODS: By means of orthogonal polarization spectral imaging, a qualitative and quantitative analysis of cortical microcirculation was performed during aneurysm surgery in 3 patients with an incidental intracerebral aneurysm and 10 patients with SAH. Vessel diameters, red blood cell velocity, and functional capillary density were analyzed before and after the aneurysm was clipped. RESULTS: Initial capillary density in patients with an incidental aneurysm was 91.5 ± 36.5 cm-1 (mean ± standard deviation) compared with 30.5 ± 13.8 in patients with SAH (P < 0.05). In patients with SAH, capillary density increased significantly to 53.9 ± 29.1 cm-1 (P < 0.05) during the operation, as did the frequency of venules with a red blood cell velocity greater than 2 mm/s (P < 0.05). No significant change of arteriolar or venular diameters was observed. However, in patients with SAH, mono- and multisegmental microvasospasms in arterioles were observed, with a reduction of vessel diameters up to 75.1%. CONCLUSION: Orthogonal polarization spectral imaging is a suitable method to study cerebral microcirculation during surgery. In patients with SAH, capillary density is significantly decreased and small arteries and arterioles of the cortical surface exhibit vasospasm that cannot be detected by angiography or transcranial Doppler sonography. These changes may contribute to the initial clinical symptoms and may have an influence on the clinical postoperative course.

AB - OBJECTIVE: Changes of major cerebral vessels in patients with subarachnoid hemorrhage (SAH) are well known from routine cerebral angiography. Data on changes in the microcirculation do not exist. This study sought to provide a qualitative and quantitative analysis of the cortical microcirculation after SAH. METHODS: By means of orthogonal polarization spectral imaging, a qualitative and quantitative analysis of cortical microcirculation was performed during aneurysm surgery in 3 patients with an incidental intracerebral aneurysm and 10 patients with SAH. Vessel diameters, red blood cell velocity, and functional capillary density were analyzed before and after the aneurysm was clipped. RESULTS: Initial capillary density in patients with an incidental aneurysm was 91.5 ± 36.5 cm-1 (mean ± standard deviation) compared with 30.5 ± 13.8 in patients with SAH (P < 0.05). In patients with SAH, capillary density increased significantly to 53.9 ± 29.1 cm-1 (P < 0.05) during the operation, as did the frequency of venules with a red blood cell velocity greater than 2 mm/s (P < 0.05). No significant change of arteriolar or venular diameters was observed. However, in patients with SAH, mono- and multisegmental microvasospasms in arterioles were observed, with a reduction of vessel diameters up to 75.1%. CONCLUSION: Orthogonal polarization spectral imaging is a suitable method to study cerebral microcirculation during surgery. In patients with SAH, capillary density is significantly decreased and small arteries and arterioles of the cortical surface exhibit vasospasm that cannot be detected by angiography or transcranial Doppler sonography. These changes may contribute to the initial clinical symptoms and may have an influence on the clinical postoperative course.

KW - Aneurysm surgery

KW - Cerebral microcirculation

KW - Orthogonal polarization

KW - Spectral imaging

KW - Subarachnoid hemorrhage

KW - Vasospasm

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