Intraoperative measurement of cortical oxygen saturation and blood volume adjacent to cerebral arteriovenous malformations using near-infrared spectroscopy

Siamak Asgari, Hans Joachim Röhrborn, Tobias Engelhorn, Barbara Fauser, Dietmar Stolke, H. Hunt Batjer, John Sinclair, Gary K. Steinberg, Chi Shing Zee, David A. Omahen, J. Max Findlay, Christopher S. Ogilvy

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20 Scopus citations

Abstract

OBJECTIVE: Both cortical oxygen saturation (SaO2) and cortical blood volume (BV) are related to regional cerebral blood flow. Among a series of patients with cerebral arteriovenous malformations, we examined the problem of hyperemia after embolization/resection or resection with the intraoperative application of near-infrared spectroscopy. METHODS: Cortical SaO2 and BV (intracapillary total hemoglobin concentrations) were measured, with near-infrared spectroscopy, in areas adjacent to the arteriovenous malformation for 20 patients, before and after resection. The absolute values for both parameters and postexcision/preexcision ratios (P-P ratios) were determined. Data were correlated with multiple clinical and preoperative angiographic parameters. RESULTS: Before resection, the mean SaO2 was 49 ± 16% and the mean BV was 12.65 ± 7.41 mg/ml. After resection, SaO2 increased for 17 of 20 patients and BV increased for 18 of 20 patients. The differences between pre- and postexcision values for both parameters were observed to be statistically significant (P<0.01). The average P-P ratios were 1.5 ± 0.4 for SaO2 and 1.7 ± 0.4 for BV. Correlation between the P-P ratios for the two parameters was good. The initial BV and the P-P ratios for both SaO2 and BV were exclusively dependent on the extent of preoperative embolization. Postoperatively, two patients developed intracerebral hemorrhage or severe edema. Both demonstrated high P-P ratios for SaO2 (2.3 and 2.1) and BV (1.6 and 2.1). CONCLUSION: Intraoperative near-infrared spectroscopy is able to detect the hyperemic status of adjacent cortex after arteriovenous malformation resection. However, staged therapy with embolization and surgery results in less hyperemia after resection. While two patients with hyperemic complications exhibited very large increases in SaO2 and BV, we cannot refute the normal-perfusion pressure breakthrough theory.

Original languageEnglish (US)
Pages (from-to)1298-1306
Number of pages9
JournalNeurosurgery
Volume52
Issue number6
Publication statusPublished - Jun 1 2003

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Keywords

  • Blood volume
  • Cerebral arteriovenous malformation
  • Near-infrared spectroscopy
  • Oxygen saturation

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

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