Abstract
A recent controlled American trial of treatment for Kawasaki disease compared the use of acetylsalicylic acid (aspirin) alone v aspirin at the same dose plus a single preparation of IV γ-globulin, which is not currently licensed in the United States. The dosage of IV γ-globulin was 400 mg/kg/d for four days, and the dosage of aspirin was 80 to 100 mg/kg/d for as many as 8 weeks. The results indicated that, if administered within ten days of onset of fever, the combined treatment significantly lowered the prevalence of coronary artery dilation and aneurysms detected at 2 and 7 weeks postenrollment. The IV γ-globulin-treated group showed significant and rapid reduction in fever, WBC count, and generalized inflammatory signs. Prior studies in Japan also showed benefit from IV γ-globulin.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 122 |
| Number of pages | 1 |
| Journal | Pediatrics |
| Volume | 82 |
| Issue number | 1 |
| State | Published - 1988 |
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ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
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Intravenous γ-globulin use in children with Kawasaki disease. / Plotkin, S. A.; Daum, R. S.; Giebink, G. S.; Hall, C. B.; Lepow, M.; Marcuse, E. K.; McCracken, G. H.; Phillips, C. F.; Scott, G. B.; Wright, H. T.; Peter, G.; Hinman, A. R.; Parkman, P.; Gold, R.; Easton, J. G.
In: Pediatrics, Vol. 82, No. 1, 1988, p. 122.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Intravenous γ-globulin use in children with Kawasaki disease
AU - Plotkin, S. A.
AU - Daum, R. S.
AU - Giebink, G. S.
AU - Hall, C. B.
AU - Lepow, M.
AU - Marcuse, E. K.
AU - McCracken, G. H.
AU - Phillips, C. F.
AU - Scott, G. B.
AU - Wright, H. T.
AU - Peter, G.
AU - Hinman, A. R.
AU - Parkman, P.
AU - Gold, R.
AU - Easton, J. G.
PY - 1988
Y1 - 1988
N2 - A recent controlled American trial of treatment for Kawasaki disease compared the use of acetylsalicylic acid (aspirin) alone v aspirin at the same dose plus a single preparation of IV γ-globulin, which is not currently licensed in the United States. The dosage of IV γ-globulin was 400 mg/kg/d for four days, and the dosage of aspirin was 80 to 100 mg/kg/d for as many as 8 weeks. The results indicated that, if administered within ten days of onset of fever, the combined treatment significantly lowered the prevalence of coronary artery dilation and aneurysms detected at 2 and 7 weeks postenrollment. The IV γ-globulin-treated group showed significant and rapid reduction in fever, WBC count, and generalized inflammatory signs. Prior studies in Japan also showed benefit from IV γ-globulin.
AB - A recent controlled American trial of treatment for Kawasaki disease compared the use of acetylsalicylic acid (aspirin) alone v aspirin at the same dose plus a single preparation of IV γ-globulin, which is not currently licensed in the United States. The dosage of IV γ-globulin was 400 mg/kg/d for four days, and the dosage of aspirin was 80 to 100 mg/kg/d for as many as 8 weeks. The results indicated that, if administered within ten days of onset of fever, the combined treatment significantly lowered the prevalence of coronary artery dilation and aneurysms detected at 2 and 7 weeks postenrollment. The IV γ-globulin-treated group showed significant and rapid reduction in fever, WBC count, and generalized inflammatory signs. Prior studies in Japan also showed benefit from IV γ-globulin.
UR - http://www.scopus.com/inward/record.url?scp=0023932233&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023932233&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0023932233
VL - 82
SP - 122
JO - Pediatrics
JF - Pediatrics
SN - 0031-4005
IS - 1
ER -