Investigation into Possible Association of Oxandrolone and Heterotopic Ossification Following Burn Injury

Catherine R. Thorpe, Serra Ucer Ozgurel, Laura C. Simko, Richard Goldstein, Gabrielle G. Grant, Chase Pagani, Charles Hwang, Kaetlin Vasquez, Michael Sorkin, Anita Vaishampayan, Jeremy Goverman, Robert L. Sheridan, Jonathan Friedstat, John T. Schulz, Jeffrey C. Schneider, Benjamin Levi, Colleen M. Ryan

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Oxandrolone, a testosterone analog, is used to counteract the catabolic effects of burn injury. Recent animal studies suggest a possible hormonal association with heterotopic ossification (HO) development postburn. This work examines oxandrolone administration and HO development by exploring historical clinical data bridging the introduction of oxandrolone into clinical practice. Additionally, we examine associations between oxandrolone administration and HO in a standardized mouse model of burn/trauma-related HO. Acutely burned adults admitted between 2000 and 2014, survived through discharge, and had a HO risk factor of 7 or higher were selected for analysis from a single burn center. Oxandrolone administration, clinical and demographic data, and elbow HO were recorded and were analyzed with logistic regression. Associations of oxandrolone with HO were examined in a mouse model. Mice were administered oxandrolone or vehicle control following burn/tenotomy to examine any potential effect of oxandrolone on HO and were analyzed by Student's t test. Subjects who received oxandrolone had a higher incidence of elbow HO than those that did not receive oxandrolone. However, when controlling for oxandrolone administration, oxandrolone duration, postburn day oxandrolone initiation, HO risk score category, age, sex, race, burn size, and year of injury, there was no significant difference between rates of elbow HO between the two populations. In agreement with the review, in the mouse model, while there was a trend toward the oxandrolone group developing a greater volume of HO, this did not reach statistical significance.

Original languageEnglish (US)
Article numberirz063
Pages (from-to)398-405
Number of pages8
JournalJournal of Burn Care and Research
Volume40
Issue number4
DOIs
StatePublished - Jun 21 2019
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Emergency Medicine
  • Rehabilitation

Fingerprint

Dive into the research topics of 'Investigation into Possible Association of Oxandrolone and Heterotopic Ossification Following Burn Injury'. Together they form a unique fingerprint.

Cite this