Iodine 123-phenylpentadecanoic acid myocardial scintigraphy: Usefulness in the identification of myocardial ischemia

P. L. Kennedy, J. R. Corbett, P. V. Kulkarni, C. L. Wolfe, D. E. Jansen, C. L. Hansen, L. M. Buja, R. W. Parkey, J. T. Willerson

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Abstract

In this study, we tested the hypothesis that myocardial ischemia induced by exercise in patients is associated with diminished metabolism and/or delayed clearance of an intravenously injected fatty acid, iodine 123-labeled phenylpentadecanoic acid (IPPA). Fifteen normal volunteers and 18 patients with significant coronary heart disease (CHD) received IPPA during exercise. In the patients with CHD, radionuclide ventriculograms were also obtained during exercise. The normal volunteers had relatively uniform initial left ventricular segmental IPPA activity after exercise and uniform IPPA clearance in the interval from 4 to 20 min immediately after exercise. In contrast, the patients with CHD had increased initial left ventricular segmental IPPA activity (63%, p < .001) and delayed IPPA clearance (44%, p < .01) in segments supplied by significantly narrowed coronary arteries. Based on analysis with the mean values ± 1 SD for initial IPPA activity, clearance, or both in normal volunteers, the sensitivity and specificity of exercise IPPA scintigraphy for detecting CHD were 89% and 67%, respectively; when ± 2 SD differences from the mean values in the normal volunteers were considered, the sensitivity and specificity were 72% and 100%, respectively. Among the total of 27 noninfarcted left ventricular segments supplied by significantly narrowed coronary arteries in the study patients, 26 (96%) had an abnormality (mean ± 1 SD) of either initial IPPA activity or clearance compared with corresponding segments in the normal volunteers and/or with other left ventricular segments in the same image that were not supplied by significantly narrowed coronary arteries. Thus, these data suggest that IPPA scintigraphy may be used in the identification of myocardial ischemia in patients with CHD by demonstrating abnormal initial left ventricular segmental IPPA activity and/or delayed clearance after exercise.

Original languageEnglish (US)
Pages (from-to)1007-1015
Number of pages9
JournalCirculation
Volume74
Issue number5
StatePublished - 1986

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Myocardial Perfusion Imaging
Iodine
Myocardial Ischemia
Acids
Exercise
Coronary Disease
Healthy Volunteers
Coronary Vessels
Radionuclide Imaging
Sensitivity and Specificity
Radioisotopes
Fatty Acids

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Kennedy, P. L., Corbett, J. R., Kulkarni, P. V., Wolfe, C. L., Jansen, D. E., Hansen, C. L., ... Willerson, J. T. (1986). Iodine 123-phenylpentadecanoic acid myocardial scintigraphy: Usefulness in the identification of myocardial ischemia. Circulation, 74(5), 1007-1015.

Iodine 123-phenylpentadecanoic acid myocardial scintigraphy : Usefulness in the identification of myocardial ischemia. / Kennedy, P. L.; Corbett, J. R.; Kulkarni, P. V.; Wolfe, C. L.; Jansen, D. E.; Hansen, C. L.; Buja, L. M.; Parkey, R. W.; Willerson, J. T.

In: Circulation, Vol. 74, No. 5, 1986, p. 1007-1015.

Research output: Contribution to journalArticle

Kennedy, PL, Corbett, JR, Kulkarni, PV, Wolfe, CL, Jansen, DE, Hansen, CL, Buja, LM, Parkey, RW & Willerson, JT 1986, 'Iodine 123-phenylpentadecanoic acid myocardial scintigraphy: Usefulness in the identification of myocardial ischemia', Circulation, vol. 74, no. 5, pp. 1007-1015.
Kennedy PL, Corbett JR, Kulkarni PV, Wolfe CL, Jansen DE, Hansen CL et al. Iodine 123-phenylpentadecanoic acid myocardial scintigraphy: Usefulness in the identification of myocardial ischemia. Circulation. 1986;74(5):1007-1015.
Kennedy, P. L. ; Corbett, J. R. ; Kulkarni, P. V. ; Wolfe, C. L. ; Jansen, D. E. ; Hansen, C. L. ; Buja, L. M. ; Parkey, R. W. ; Willerson, J. T. / Iodine 123-phenylpentadecanoic acid myocardial scintigraphy : Usefulness in the identification of myocardial ischemia. In: Circulation. 1986 ; Vol. 74, No. 5. pp. 1007-1015.
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abstract = "In this study, we tested the hypothesis that myocardial ischemia induced by exercise in patients is associated with diminished metabolism and/or delayed clearance of an intravenously injected fatty acid, iodine 123-labeled phenylpentadecanoic acid (IPPA). Fifteen normal volunteers and 18 patients with significant coronary heart disease (CHD) received IPPA during exercise. In the patients with CHD, radionuclide ventriculograms were also obtained during exercise. The normal volunteers had relatively uniform initial left ventricular segmental IPPA activity after exercise and uniform IPPA clearance in the interval from 4 to 20 min immediately after exercise. In contrast, the patients with CHD had increased initial left ventricular segmental IPPA activity (63{\%}, p < .001) and delayed IPPA clearance (44{\%}, p < .01) in segments supplied by significantly narrowed coronary arteries. Based on analysis with the mean values ± 1 SD for initial IPPA activity, clearance, or both in normal volunteers, the sensitivity and specificity of exercise IPPA scintigraphy for detecting CHD were 89{\%} and 67{\%}, respectively; when ± 2 SD differences from the mean values in the normal volunteers were considered, the sensitivity and specificity were 72{\%} and 100{\%}, respectively. Among the total of 27 noninfarcted left ventricular segments supplied by significantly narrowed coronary arteries in the study patients, 26 (96{\%}) had an abnormality (mean ± 1 SD) of either initial IPPA activity or clearance compared with corresponding segments in the normal volunteers and/or with other left ventricular segments in the same image that were not supplied by significantly narrowed coronary arteries. Thus, these data suggest that IPPA scintigraphy may be used in the identification of myocardial ischemia in patients with CHD by demonstrating abnormal initial left ventricular segmental IPPA activity and/or delayed clearance after exercise.",
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T2 - Usefulness in the identification of myocardial ischemia

AU - Kennedy, P. L.

AU - Corbett, J. R.

AU - Kulkarni, P. V.

AU - Wolfe, C. L.

AU - Jansen, D. E.

AU - Hansen, C. L.

AU - Buja, L. M.

AU - Parkey, R. W.

AU - Willerson, J. T.

PY - 1986

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N2 - In this study, we tested the hypothesis that myocardial ischemia induced by exercise in patients is associated with diminished metabolism and/or delayed clearance of an intravenously injected fatty acid, iodine 123-labeled phenylpentadecanoic acid (IPPA). Fifteen normal volunteers and 18 patients with significant coronary heart disease (CHD) received IPPA during exercise. In the patients with CHD, radionuclide ventriculograms were also obtained during exercise. The normal volunteers had relatively uniform initial left ventricular segmental IPPA activity after exercise and uniform IPPA clearance in the interval from 4 to 20 min immediately after exercise. In contrast, the patients with CHD had increased initial left ventricular segmental IPPA activity (63%, p < .001) and delayed IPPA clearance (44%, p < .01) in segments supplied by significantly narrowed coronary arteries. Based on analysis with the mean values ± 1 SD for initial IPPA activity, clearance, or both in normal volunteers, the sensitivity and specificity of exercise IPPA scintigraphy for detecting CHD were 89% and 67%, respectively; when ± 2 SD differences from the mean values in the normal volunteers were considered, the sensitivity and specificity were 72% and 100%, respectively. Among the total of 27 noninfarcted left ventricular segments supplied by significantly narrowed coronary arteries in the study patients, 26 (96%) had an abnormality (mean ± 1 SD) of either initial IPPA activity or clearance compared with corresponding segments in the normal volunteers and/or with other left ventricular segments in the same image that were not supplied by significantly narrowed coronary arteries. Thus, these data suggest that IPPA scintigraphy may be used in the identification of myocardial ischemia in patients with CHD by demonstrating abnormal initial left ventricular segmental IPPA activity and/or delayed clearance after exercise.

AB - In this study, we tested the hypothesis that myocardial ischemia induced by exercise in patients is associated with diminished metabolism and/or delayed clearance of an intravenously injected fatty acid, iodine 123-labeled phenylpentadecanoic acid (IPPA). Fifteen normal volunteers and 18 patients with significant coronary heart disease (CHD) received IPPA during exercise. In the patients with CHD, radionuclide ventriculograms were also obtained during exercise. The normal volunteers had relatively uniform initial left ventricular segmental IPPA activity after exercise and uniform IPPA clearance in the interval from 4 to 20 min immediately after exercise. In contrast, the patients with CHD had increased initial left ventricular segmental IPPA activity (63%, p < .001) and delayed IPPA clearance (44%, p < .01) in segments supplied by significantly narrowed coronary arteries. Based on analysis with the mean values ± 1 SD for initial IPPA activity, clearance, or both in normal volunteers, the sensitivity and specificity of exercise IPPA scintigraphy for detecting CHD were 89% and 67%, respectively; when ± 2 SD differences from the mean values in the normal volunteers were considered, the sensitivity and specificity were 72% and 100%, respectively. Among the total of 27 noninfarcted left ventricular segments supplied by significantly narrowed coronary arteries in the study patients, 26 (96%) had an abnormality (mean ± 1 SD) of either initial IPPA activity or clearance compared with corresponding segments in the normal volunteers and/or with other left ventricular segments in the same image that were not supplied by significantly narrowed coronary arteries. Thus, these data suggest that IPPA scintigraphy may be used in the identification of myocardial ischemia in patients with CHD by demonstrating abnormal initial left ventricular segmental IPPA activity and/or delayed clearance after exercise.

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