Ion channels in digestive health and disease

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The field of ion channel research has grown tremendously since the first ion channel was cloned in the early 1980's. Techniques such as patch clamp recording and x-ray crystallography have revolutionized the study of ion channel biology, and newer techniques continue to be developed promising continued progress in clarifying the relationship between channel structure and function. Many channelopathies have been discovered and more will likely be described as the molecular identity of ion channels continues to be unraveled. As ion channels contribute to so many basic cellular processes, it is anticipated that elucidating their function and role will contribute to our basic understanding of human physiology. Additionally, understanding the complex regulation of these proteins will hopefully suggest new therapeutic interventions to treat many diseases. In the gastrointestinal system, targeting ion channels may provide treatment strategies for a number of disorders including motility disturbances, visceral pain syndromes, diarrheal illnesses, pancreatic disease, cholestasis, and liver injury associated with oxidative stress, ischemia/reperfusion, steatosis, and organ preservation injury to name just a few. There is still much work to be done to define the many ion channels of the gastrointestinal system, however it promises to be an exciting time with many rewards!

Original languageEnglish (US)
Pages (from-to)230-241
Number of pages12
JournalJournal of Pediatric Gastroenterology and Nutrition
Volume37
Issue number3
DOIs
StatePublished - Sep 2003

Fingerprint

ion channels
Ion Channels
Health
gastrointestinal system
pancreatic diseases
Channelopathies
Visceral Pain
human physiology
crystallography
Organ Preservation
cholestasis
Pancreatic Diseases
Crystallography
Cholestasis
Wounds and Injuries
ischemia
Reward
Reperfusion
Names
pain

ASJC Scopus subject areas

  • Gastroenterology
  • Histology
  • Medicine (miscellaneous)
  • Food Science
  • Pediatrics, Perinatology, and Child Health

Cite this

Ion channels in digestive health and disease. / Feranchak, Andrew P.

In: Journal of Pediatric Gastroenterology and Nutrition, Vol. 37, No. 3, 09.2003, p. 230-241.

Research output: Contribution to journalArticle

@article{59d500b98ea5458dbc6c388952fd5ae1,
title = "Ion channels in digestive health and disease",
abstract = "The field of ion channel research has grown tremendously since the first ion channel was cloned in the early 1980's. Techniques such as patch clamp recording and x-ray crystallography have revolutionized the study of ion channel biology, and newer techniques continue to be developed promising continued progress in clarifying the relationship between channel structure and function. Many channelopathies have been discovered and more will likely be described as the molecular identity of ion channels continues to be unraveled. As ion channels contribute to so many basic cellular processes, it is anticipated that elucidating their function and role will contribute to our basic understanding of human physiology. Additionally, understanding the complex regulation of these proteins will hopefully suggest new therapeutic interventions to treat many diseases. In the gastrointestinal system, targeting ion channels may provide treatment strategies for a number of disorders including motility disturbances, visceral pain syndromes, diarrheal illnesses, pancreatic disease, cholestasis, and liver injury associated with oxidative stress, ischemia/reperfusion, steatosis, and organ preservation injury to name just a few. There is still much work to be done to define the many ion channels of the gastrointestinal system, however it promises to be an exciting time with many rewards!",
author = "Feranchak, {Andrew P.}",
year = "2003",
month = "9",
doi = "10.1097/00005176-200309000-00006",
language = "English (US)",
volume = "37",
pages = "230--241",
journal = "Journal of Pediatric Gastroenterology and Nutrition",
issn = "0277-2116",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - Ion channels in digestive health and disease

AU - Feranchak, Andrew P.

PY - 2003/9

Y1 - 2003/9

N2 - The field of ion channel research has grown tremendously since the first ion channel was cloned in the early 1980's. Techniques such as patch clamp recording and x-ray crystallography have revolutionized the study of ion channel biology, and newer techniques continue to be developed promising continued progress in clarifying the relationship between channel structure and function. Many channelopathies have been discovered and more will likely be described as the molecular identity of ion channels continues to be unraveled. As ion channels contribute to so many basic cellular processes, it is anticipated that elucidating their function and role will contribute to our basic understanding of human physiology. Additionally, understanding the complex regulation of these proteins will hopefully suggest new therapeutic interventions to treat many diseases. In the gastrointestinal system, targeting ion channels may provide treatment strategies for a number of disorders including motility disturbances, visceral pain syndromes, diarrheal illnesses, pancreatic disease, cholestasis, and liver injury associated with oxidative stress, ischemia/reperfusion, steatosis, and organ preservation injury to name just a few. There is still much work to be done to define the many ion channels of the gastrointestinal system, however it promises to be an exciting time with many rewards!

AB - The field of ion channel research has grown tremendously since the first ion channel was cloned in the early 1980's. Techniques such as patch clamp recording and x-ray crystallography have revolutionized the study of ion channel biology, and newer techniques continue to be developed promising continued progress in clarifying the relationship between channel structure and function. Many channelopathies have been discovered and more will likely be described as the molecular identity of ion channels continues to be unraveled. As ion channels contribute to so many basic cellular processes, it is anticipated that elucidating their function and role will contribute to our basic understanding of human physiology. Additionally, understanding the complex regulation of these proteins will hopefully suggest new therapeutic interventions to treat many diseases. In the gastrointestinal system, targeting ion channels may provide treatment strategies for a number of disorders including motility disturbances, visceral pain syndromes, diarrheal illnesses, pancreatic disease, cholestasis, and liver injury associated with oxidative stress, ischemia/reperfusion, steatosis, and organ preservation injury to name just a few. There is still much work to be done to define the many ion channels of the gastrointestinal system, however it promises to be an exciting time with many rewards!

UR - http://www.scopus.com/inward/record.url?scp=1542472117&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=1542472117&partnerID=8YFLogxK

U2 - 10.1097/00005176-200309000-00006

DO - 10.1097/00005176-200309000-00006

M3 - Article

VL - 37

SP - 230

EP - 241

JO - Journal of Pediatric Gastroenterology and Nutrition

JF - Journal of Pediatric Gastroenterology and Nutrition

SN - 0277-2116

IS - 3

ER -