Is it a safe practice to administer oxygen during uncomplicated delivery: A randomized controlled trial?

Tetyana H. Nesterenko, Ceyda Acun, Mohamed A. Mohamed, Ahmed N. Mohamed, Donald Karcher, John Larsen, Hany Aly

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Background: Newborns exposed to oxygen suffer from an oxidative stress with significant alterations in the concentrations of superoxide dismutase (SOD) and glutathione (GSSG). Objective: To investigate the biological and clinical effects of oxygen administration to delivering mothers. Methods: We conducted a randomized, double-blinded, controlled trial on a cohort of delivering women (n = 56) with an uncomplicated term pregnancy. Women were randomly assigned to one of two groups: Oxygen group or Room Air group. The Oxygen group received 100% oxygen (2. l/min) via nasal cannula for at least 30. min before delivery. Subjects in the Room Air group were connected to a nasal cannula while on room air. Concentrations of SOD (μg/g of Hb) and GSSG (μM/ml) were measured in maternal and umbilical cord blood. Bivariate and multivariate analyses were used to compare the two groups using the SAS system. Results: Maternal SOD and GSSG did not differ between the two groups at baseline or after delivery. Concentrations of SOD and GSSG in umbilical cord blood did not differ between groups. More infants in Oxygen Group required delivery room resuscitation (20% vs. 0%, P = 0.03). This difference could not be explained by mode of delivery, infant sex, or other confounders. Conclusions: Maternal exposure to oxygen during delivery is not associated with changes in umbilical cord SOD or GSSG. Further studies are needed to explore mechanisms responsible for the need of resuscitation in the oxygen group.

Original languageEnglish (US)
Pages (from-to)677-681
Number of pages5
JournalEarly Human Development
Volume88
Issue number8
DOIs
StatePublished - Aug 1 2012

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Randomized Controlled Trials
Glutathione Disulfide
Oxygen
Superoxide Dismutase
Air
Mothers
Fetal Blood
Resuscitation
Delivery Rooms
Maternal Exposure
Umbilical Cord
Glutathione
Oxidative Stress
Multivariate Analysis
Newborn Infant
Pregnancy

Keywords

  • Cesarean delivery
  • Glutathione peroxidase
  • Oxidative stress
  • Oxygen free radicals
  • Superoxide dismutase

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

Cite this

Is it a safe practice to administer oxygen during uncomplicated delivery : A randomized controlled trial? / Nesterenko, Tetyana H.; Acun, Ceyda; Mohamed, Mohamed A.; Mohamed, Ahmed N.; Karcher, Donald; Larsen, John; Aly, Hany.

In: Early Human Development, Vol. 88, No. 8, 01.08.2012, p. 677-681.

Research output: Contribution to journalArticle

Nesterenko, Tetyana H. ; Acun, Ceyda ; Mohamed, Mohamed A. ; Mohamed, Ahmed N. ; Karcher, Donald ; Larsen, John ; Aly, Hany. / Is it a safe practice to administer oxygen during uncomplicated delivery : A randomized controlled trial?. In: Early Human Development. 2012 ; Vol. 88, No. 8. pp. 677-681.
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AU - Mohamed, Ahmed N.

AU - Karcher, Donald

AU - Larsen, John

AU - Aly, Hany

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N2 - Background: Newborns exposed to oxygen suffer from an oxidative stress with significant alterations in the concentrations of superoxide dismutase (SOD) and glutathione (GSSG). Objective: To investigate the biological and clinical effects of oxygen administration to delivering mothers. Methods: We conducted a randomized, double-blinded, controlled trial on a cohort of delivering women (n = 56) with an uncomplicated term pregnancy. Women were randomly assigned to one of two groups: Oxygen group or Room Air group. The Oxygen group received 100% oxygen (2. l/min) via nasal cannula for at least 30. min before delivery. Subjects in the Room Air group were connected to a nasal cannula while on room air. Concentrations of SOD (μg/g of Hb) and GSSG (μM/ml) were measured in maternal and umbilical cord blood. Bivariate and multivariate analyses were used to compare the two groups using the SAS system. Results: Maternal SOD and GSSG did not differ between the two groups at baseline or after delivery. Concentrations of SOD and GSSG in umbilical cord blood did not differ between groups. More infants in Oxygen Group required delivery room resuscitation (20% vs. 0%, P = 0.03). This difference could not be explained by mode of delivery, infant sex, or other confounders. Conclusions: Maternal exposure to oxygen during delivery is not associated with changes in umbilical cord SOD or GSSG. Further studies are needed to explore mechanisms responsible for the need of resuscitation in the oxygen group.

AB - Background: Newborns exposed to oxygen suffer from an oxidative stress with significant alterations in the concentrations of superoxide dismutase (SOD) and glutathione (GSSG). Objective: To investigate the biological and clinical effects of oxygen administration to delivering mothers. Methods: We conducted a randomized, double-blinded, controlled trial on a cohort of delivering women (n = 56) with an uncomplicated term pregnancy. Women were randomly assigned to one of two groups: Oxygen group or Room Air group. The Oxygen group received 100% oxygen (2. l/min) via nasal cannula for at least 30. min before delivery. Subjects in the Room Air group were connected to a nasal cannula while on room air. Concentrations of SOD (μg/g of Hb) and GSSG (μM/ml) were measured in maternal and umbilical cord blood. Bivariate and multivariate analyses were used to compare the two groups using the SAS system. Results: Maternal SOD and GSSG did not differ between the two groups at baseline or after delivery. Concentrations of SOD and GSSG in umbilical cord blood did not differ between groups. More infants in Oxygen Group required delivery room resuscitation (20% vs. 0%, P = 0.03). This difference could not be explained by mode of delivery, infant sex, or other confounders. Conclusions: Maternal exposure to oxygen during delivery is not associated with changes in umbilical cord SOD or GSSG. Further studies are needed to explore mechanisms responsible for the need of resuscitation in the oxygen group.

KW - Cesarean delivery

KW - Glutathione peroxidase

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