Is mitochondrial dysfunction a common root of noncommunicable chronic diseases?

Alexis Diaz-Vegas; Pablo Sanchez-Aguilera; James R. Krycer; Pablo E. Morales; Matías Monsalves-Alvarez; Mariana Cifuentes; Beverly A. Rothermel; Sergio Lavandero

doi:10.1210/ENDREV/BNAA005

Is mitochondrial dysfunction a common root of noncommunicable chronic diseases?

Alexis Diaz-Vegas, Pablo Sanchez-Aguilera, James R. Krycer, Pablo E. Morales, Matías Monsalves-Alvarez, Mariana Cifuentes, Beverly A. Rothermel, Sergio Lavandero

Research output: Contribution to journal › Review article › peer-review

75 Scopus citations

Abstract

Mitochondrial damage is implicated as a major contributing factor for a number of noncommunicable chronic diseases such as cardiovascular diseases, cancer, obesity, and insulin resistance/type 2 diabetes. Here, we discuss the role of mitochondria in maintaining cellular and whole-organism homeostasis, the mechanisms that promote mitochondrial dysfunction, and the role of this phenomenon in noncommunicable chronic diseases. We also review the state of the art regarding the preclinical evidence associated with the regulation of mitochondrial function and the development of current mitochondria-targeted therapeutics to treat noncommunicable chronic diseases. Finally, we give an integrated vision of how mitochondrial damage is implicated in these metabolic diseases.

Original language	English (US)
Pages (from-to)	491-517
Number of pages	27
Journal	Endocrine reviews
Volume	41
Issue number	3
DOIs	https://doi.org/10.1210/ENDREV/BNAA005
State	Published - 2021

Keywords

Cancer
Cardiovascular diseases
Insulin resistance
Mitochondria
Obesity

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology

Access to Document

10.1210/ENDREV/BNAA005

Cite this

@article{7b8394c59a75484ba88a62984cde238c,

title = "Is mitochondrial dysfunction a common root of noncommunicable chronic diseases?",

abstract = "Mitochondrial damage is implicated as a major contributing factor for a number of noncommunicable chronic diseases such as cardiovascular diseases, cancer, obesity, and insulin resistance/type 2 diabetes. Here, we discuss the role of mitochondria in maintaining cellular and whole-organism homeostasis, the mechanisms that promote mitochondrial dysfunction, and the role of this phenomenon in noncommunicable chronic diseases. We also review the state of the art regarding the preclinical evidence associated with the regulation of mitochondrial function and the development of current mitochondria-targeted therapeutics to treat noncommunicable chronic diseases. Finally, we give an integrated vision of how mitochondrial damage is implicated in these metabolic diseases.",

keywords = "Cancer, Cardiovascular diseases, Insulin resistance, Mitochondria, Obesity",

author = "Alexis Diaz-Vegas and Pablo Sanchez-Aguilera and Krycer, {James R.} and Morales, {Pablo E.} and Mat{\'i}as Monsalves-Alvarez and Mariana Cifuentes and Rothermel, {Beverly A.} and Sergio Lavandero",

note = "Funding Information: This work was supported by grants to S.L. from the Agencia Nacional de Investigacion y Desarrollo (ANID), Chile: FONDECYT 1161156, FONDECYT 1200490 and FONDAP 15130011). We are also thankful for the PhD fellowships from CONICYT Chile to P.S.A., P.E.M. Grants to B.A.R. from the American Heart Association (19TPA34920001), the National Institutes of Health (RO1HD101006), and the Australian National Health and Medical Research Council (APP1142403). Grant to M.C. from Proyecto de Enlace ENL 18/19, VID, Universidad de Chile. Grant to A.D.V. from Australian Research Council (DP180103482). Publisher Copyright: {\textcopyright} Endocrine Society 2020.",

year = "2021",

doi = "10.1210/ENDREV/BNAA005",

language = "English (US)",

volume = "41",

pages = "491--517",

journal = "Endocrine reviews",

issn = "0163-769X",