Is Mitochondrial Dysfunction a Common Root of Noncommunicable Chronic Diseases?

Alexis Diaz-Vegas, Pablo Sanchez-Aguilera, James R. Krycer, Pablo E. Morales, Matías Monsalves-Alvarez, Mariana Cifuentes, Beverly A. Rothermel, Sergio Lavandero

Research output: Contribution to journalArticle

Abstract

Mitochondrial damage is implicated as a major contributing factor for a number of noncommunicable chronic diseases such as cardiovascular diseases, cancer, obesity, and insulin resistance/type 2 diabetes. Here, we discuss the role of mitochondria in maintaining cellular and whole-organism homeostasis, the mechanisms that promote mitochondrial dysfunction, and the role of this phenomenon in noncommunicable chronic diseases. We also review the state of the art regarding the preclinical evidence associated with the regulation of mitochondrial function and the development of current mitochondria-targeted therapeutics to treat noncommunicable chronic diseases. Finally, we give an integrated vision of how mitochondrial damage is implicated in these metabolic diseases.

Original languageEnglish (US)
JournalEndocrine reviews
Volume41
Issue number3
DOIs
StatePublished - Jun 1 2020

Keywords

  • mitochondria
  • cancer
  • cardiovascular diseases
  • insulin resistance
  • obesity

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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    Diaz-Vegas, A., Sanchez-Aguilera, P., Krycer, J. R., Morales, P. E., Monsalves-Alvarez, M., Cifuentes, M., Rothermel, B. A., & Lavandero, S. (2020). Is Mitochondrial Dysfunction a Common Root of Noncommunicable Chronic Diseases? Endocrine reviews, 41(3). https://doi.org/10.1210/endrev/bnaa005