Is there a learning curve associated with the use of remifentanil?

Girish P. Joshi, Brenda D. Jamerson, Michael F. Roizen, Lee Fleisher, Rebecca S. Twersky, David S. Warner, Michael Colopy

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

This study prospectively determined whether there was a learning curve with the use of remifentanil, as indicated by decreased hemodynamic variability, improved recovery profile, and decreased incidence of opioid-related adverse events with increasing experience. Patients undergoing diverse surgical procedures (outpatient [n = 1340] and inpatient [n = 560]) were enrolled by investigators (n = 190) who had no previous experience with remifentanil use. Each investigator enrolled 10 patients. A standardized protocol for administration of remifentanil was used. Data were analyzed to determine differences between the first three patients and the last three patients enrolled for each anesthesiologist in the study. There were no differences in hemodynamic variables between the first triad and the last triad in either outpatients or inpatients. Requirements for hypnotic drugs and the doses of remifentanil used were also similar between groups. Analgesic medications administered at the end of surgery and in the postanesthesia care unit (PACU) were similar between groups, except that the last triad in the outpatient group received smaller doses of fentanyl compared with the first triad. Times to response to verbal command, tracheal extubation, and operating room discharge did not differ between groups. However, patients in the last triad undergoing outpatient surgery had shorter times to eligibility for PACU discharge, but times to eligibility for discharge home did not differ. The overall incidence of all adverse events (i.e., hypotension, hypertension, muscle rigidity, respiratory depression, apnea, nausea, and vomiting) was less in the last triad as compared with the first triad. When analyzed separately, only the incidence of vomiting (in the outpatient group) was decreased in the last triad as compared with the first triad. This study suggests that there is a learning curve that aids reduction of minor adverse effects associated with the use of analgesic medications administered at the end of surgery in outpatients, which might have reduced the incidence of postoperative vomiting and the duration of PACU stay.

Original languageEnglish (US)
Pages (from-to)1049-1055
Number of pages7
JournalAnesthesia and Analgesia
Volume91
Issue number5
StatePublished - 2000

Fingerprint

Learning Curve
Outpatients
Incidence
Ambulatory Surgical Procedures
Vomiting
Analgesics
Inpatients
Hemodynamics
Airway Extubation
Research Personnel
Muscle Rigidity
Postoperative Nausea and Vomiting
Fentanyl
Apnea
Operating Rooms
Hypnotics and Sedatives
Respiratory Insufficiency
Hypotension
Nausea
Opioid Analgesics

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Joshi, G. P., Jamerson, B. D., Roizen, M. F., Fleisher, L., Twersky, R. S., Warner, D. S., & Colopy, M. (2000). Is there a learning curve associated with the use of remifentanil? Anesthesia and Analgesia, 91(5), 1049-1055.

Is there a learning curve associated with the use of remifentanil? / Joshi, Girish P.; Jamerson, Brenda D.; Roizen, Michael F.; Fleisher, Lee; Twersky, Rebecca S.; Warner, David S.; Colopy, Michael.

In: Anesthesia and Analgesia, Vol. 91, No. 5, 2000, p. 1049-1055.

Research output: Contribution to journalArticle

Joshi, GP, Jamerson, BD, Roizen, MF, Fleisher, L, Twersky, RS, Warner, DS & Colopy, M 2000, 'Is there a learning curve associated with the use of remifentanil?', Anesthesia and Analgesia, vol. 91, no. 5, pp. 1049-1055.
Joshi GP, Jamerson BD, Roizen MF, Fleisher L, Twersky RS, Warner DS et al. Is there a learning curve associated with the use of remifentanil? Anesthesia and Analgesia. 2000;91(5):1049-1055.
Joshi, Girish P. ; Jamerson, Brenda D. ; Roizen, Michael F. ; Fleisher, Lee ; Twersky, Rebecca S. ; Warner, David S. ; Colopy, Michael. / Is there a learning curve associated with the use of remifentanil?. In: Anesthesia and Analgesia. 2000 ; Vol. 91, No. 5. pp. 1049-1055.
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