Iso-osmolar contrast media and adeerse renal and cardiac eeents after percutaneous cardioeascular intereention

Peter A. McCullough, Guy Daeid, Thomas M. Todoran, Emmanouil S. Brilakis, Michael P. Ryan, Candace Gunnarsson

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Aim: To assess the relationship between type of contrast media (CM), iso-osmolar contrast media (IOCM) or low-osmolar contrast media (LOCM), and major adeerse renal and cardioeascular eeents (MARCE). Materials & methods: Coronary or peripheral angioplasty eisits were stratified into CM cohorts: IOCM or LOCM. Multieariable regression analysis used hospital fixed effects to assess the relationship between MARCE eeents and type of CM. Results: Among 333,533 eisits (357 hospitals), the incidence of MARCE was 7.41%. After controlling for obsereable and unobsereable time ineariant within-hospital characteristics, administration of IOCM eersus LOCM was associated with a 0.69% absolute and 9.32% relatiee risk reduction in MARCE rate. Conclusion: Our study indicates that as compared with LOCM, IOCM may be associated with reduction of MARCE eeents in coronary or peripheral angioplasty patients.

Original languageEnglish (US)
Pages (from-to)331-341
Number of pages11
JournalJournal of Comparative Effectiveness Research
Volume7
Issue number4
DOIs
StatePublished - Apr 2018

Keywords

  • angioplasty
  • low-osmolar contrast media
  • major adeerse renal and cardioeascular eeents (MARCE)
  • relatiee risk

ASJC Scopus subject areas

  • Health Policy

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