TY - JOUR
T1 - Iso-osmolar contrast media and adeerse renal and cardiac eeents after percutaneous cardioeascular intereention
AU - McCullough, Peter A.
AU - Daeid, Guy
AU - Todoran, Thomas M.
AU - Brilakis, Emmanouil S.
AU - Ryan, Michael P.
AU - Gunnarsson, Candace
N1 - Funding Information:
This study was sponsored by GE Healthcare. PA McCullough has been a consultant to GE Healthcare™. M Todoran reports personal fees from GE Healthcare. ES Brilakis reports consulting/speaker honoraria from Abbott Vascular, ACIST, Amgen, Asahi, CSI, Elsevier, GE Healthcare, Medicure and Nitiloop; research support from Boston Scientific and Osprey. C Gunnarsson and MP Ryan are employees of and G David is an academic affiliate of CTI Clinical Trial and Consulting Services, which is a paid consultant to GE Healthcare. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.
Publisher Copyright:
© 2018 Future Medicine Ltd. All rights reserved.
PY - 2018/4
Y1 - 2018/4
N2 - Aim: To assess the relationship between type of contrast media (CM), iso-osmolar contrast media (IOCM) or low-osmolar contrast media (LOCM), and major adeerse renal and cardioeascular eeents (MARCE). Materials & methods: Coronary or peripheral angioplasty eisits were stratified into CM cohorts: IOCM or LOCM. Multieariable regression analysis used hospital fixed effects to assess the relationship between MARCE eeents and type of CM. Results: Among 333,533 eisits (357 hospitals), the incidence of MARCE was 7.41%. After controlling for obsereable and unobsereable time ineariant within-hospital characteristics, administration of IOCM eersus LOCM was associated with a 0.69% absolute and 9.32% relatiee risk reduction in MARCE rate. Conclusion: Our study indicates that as compared with LOCM, IOCM may be associated with reduction of MARCE eeents in coronary or peripheral angioplasty patients.
AB - Aim: To assess the relationship between type of contrast media (CM), iso-osmolar contrast media (IOCM) or low-osmolar contrast media (LOCM), and major adeerse renal and cardioeascular eeents (MARCE). Materials & methods: Coronary or peripheral angioplasty eisits were stratified into CM cohorts: IOCM or LOCM. Multieariable regression analysis used hospital fixed effects to assess the relationship between MARCE eeents and type of CM. Results: Among 333,533 eisits (357 hospitals), the incidence of MARCE was 7.41%. After controlling for obsereable and unobsereable time ineariant within-hospital characteristics, administration of IOCM eersus LOCM was associated with a 0.69% absolute and 9.32% relatiee risk reduction in MARCE rate. Conclusion: Our study indicates that as compared with LOCM, IOCM may be associated with reduction of MARCE eeents in coronary or peripheral angioplasty patients.
KW - angioplasty
KW - low-osmolar contrast media
KW - major adeerse renal and cardioeascular eeents (MARCE)
KW - relatiee risk
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U2 - 10.2217/cer-2017-0052
DO - 10.2217/cer-2017-0052
M3 - Article
C2 - 29117715
AN - SCOPUS:85044042583
SN - 2042-6305
VL - 7
SP - 331
EP - 341
JO - Journal of Comparative Effectiveness Research
JF - Journal of Comparative Effectiveness Research
IS - 4
ER -