Isolated thrombocytopenia in children with acute lymphoblastic leukemia: A rare event in a Pediatric Oncology Group Study

A. S. Dubansky, J. M. Boyett, J. Falletta, D. H. Mahoney, V. J. Land, J. Pullen, G. Buchanan

Research output: Contribution to journalArticlepeer-review

43 Scopus citations

Abstract

To determine how many children with acute lymphoblastic leukemia initially referred to a pediatric hematologist because of isolated significant thrombocytopenia ([platelet count <50000/mm3] and an otherwise normal complete blood cell count and physical findings), a retrospective review of the Pediatric Oncology Group's charts was undertaken. Review of the records of 2239 children enrolled in the past two acute lymphoblastic leukemia protocols showed that none of these children had significant thrombocytopenia with no other hematologic or physical manifestations of acute lymphoblastic leukemia when they were first seen by the hematologist. The results suggest that routine bone marrow aspiration in the child with isolated thrombocytopenia may be unnecessary to rule out acute lymphocytic leukemia.

Original languageEnglish (US)
Pages (from-to)1068-1071
Number of pages4
JournalPediatrics
Volume84
Issue number6
StatePublished - 1989

Keywords

  • acute lymphoblastic leukemia
  • idiopathic thrombocytopenic purpura

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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