Isolation and characterization of the Haemophilus influenzae uvrA gene

Maria L. De La Morena, David R. Hendrixson, Joseph W. St. Geme

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

The uvrA gene of Haemophilus influenzae (Hi) was cloned and sequenced. Analysis of the deduced amino acid sequence revealed 81% identity and 90% similarity with the Escherichia coli UvrA protein. Consistent with a role of Hi uvrA in DNA repair, a Hi uvrA mutant exhibited increased sensitivity of UV irradiation. Furthermore, Hi uvr A was able to complement a mutation in the E. coli uvrA locus.

Original languageEnglish (US)
Pages (from-to)23-28
Number of pages6
JournalGene
Volume177
Issue number1-2
DOIs
StatePublished - Oct 24 1996

Keywords

  • DNA damage
  • DNA repair
  • Excinuclease
  • Nucleotide excision

ASJC Scopus subject areas

  • Genetics

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