Isolation and characterization of the Haemophilus influenzae uvrA gene

Maria L. De La Morena, David R. Hendrixson, Joseph W. St. Geme

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The uvrA gene of Haemophilus influenzae (Hi) was cloned and sequenced. Analysis of the deduced amino acid sequence revealed 81% identity and 90% similarity with the Escherichia coli UvrA protein. Consistent with a role of Hi uvrA in DNA repair, a Hi uvrA mutant exhibited increased sensitivity of UV irradiation. Furthermore, Hi uvr A was able to complement a mutation in the E. coli uvrA locus.

Original languageEnglish (US)
Pages (from-to)23-28
Number of pages6
JournalGene
Volume177
Issue number1-2
DOIs
StatePublished - Oct 24 1996

Fingerprint

Haemophilus influenzae
Genes
Escherichia coli Proteins
Protein Sequence Analysis
DNA Repair
Escherichia coli
Mutation

Keywords

  • DNA damage
  • DNA repair
  • Excinuclease
  • Nucleotide excision

ASJC Scopus subject areas

  • Genetics

Cite this

Isolation and characterization of the Haemophilus influenzae uvrA gene. / De La Morena, Maria L.; Hendrixson, David R.; St. Geme, Joseph W.

In: Gene, Vol. 177, No. 1-2, 24.10.1996, p. 23-28.

Research output: Contribution to journalArticle

De La Morena, Maria L. ; Hendrixson, David R. ; St. Geme, Joseph W. / Isolation and characterization of the Haemophilus influenzae uvrA gene. In: Gene. 1996 ; Vol. 177, No. 1-2. pp. 23-28.
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