Isolation and characterization of the mouse homolog of the preprodynorphin (Pdyn) gene

N. Sharifi, M. Ament, M. B. Brennan, U. Hochgeschwender

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

We have isolated and sequenced the mouse preprodynorphin gene (Pdyn). The Pdyn gene can encode for six biologically active dynorphin peptides. The predicted mouse preprodynorphin has 90%, 67%, and 66% identity with the predicted rat, porcine, and human preprodynorphins, respectively. Using an RT-PCR technique, we show that the Pdyn gene starts being expressed at embryonic day 12.5, with a steep increase of expression by embryonic day 14.5; in the adult mouse it is expressed in the brain, but not in liver, heart, spleen, or kidney.

Original languageEnglish (US)
Pages (from-to)236-238
Number of pages3
JournalNeuropeptides
Volume33
Issue number3
DOIs
StatePublished - Jun 1999

ASJC Scopus subject areas

  • Endocrinology
  • Neurology
  • Endocrine and Autonomic Systems
  • Cellular and Molecular Neuroscience

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