Isoproterenol-induced cardiomyopathy: Changes in cardiac enzymes and protection by methylprednisolone

E. A. Mueller, W. S T Griffin, K. Wildenthal

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

Subcutaneous injections of isoproterenol (80 mg.kg-1) in rats produce decreases in the total specific activities of several cardiac enzymes as well as redistribution of lysosomal enzymes from the particulate to the non-particulate fraction of tissue homogenates during the first day. Later, during the repair phase, activities of lysosomal enzymes increase markedly, co-incident with an influx of migratory cells, while activities of specific myocellular enzymes remain low. Methyl-prednisolone administered at the time of isoproterenol injection alters these responses, first by decreasing the extent of enzyme depletion and redistribution, and later by leading to reduced infiltration and proliferation of non-myocytic cells and reduced elevations of lysosomal enzymes during the repair phase.

Original languageEnglish (US)
Pages (from-to)565-578
Number of pages14
JournalJournal of Molecular and Cellular Cardiology
Volume9
Issue number7
DOIs
StatePublished - Jul 1977

Keywords

  • Acid phosphatase
  • Cathepsin D, β-Acetylglucosaminidase
  • Corticosteroids
  • Creatine phosphokinase
  • Lysosomal enzymes
  • Myocardial infarction
  • Myofibrillar alkaline proteinase

ASJC Scopus subject areas

  • Molecular Biology
  • Cardiology and Cardiovascular Medicine

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