Itch, eosinophils, and autoimmunity: A novel murine model of bullous pemphigoid

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Mice carrying a deletion in the NC14A domain of murine type XVII collagen begin scratching at age 2 months and then develop erosions, subepidermal vesicles, eosinophil-rich skin infiltrates, and autoantibodies directed against a 180 kDa skin protein that appears to be type XVII collagen. These mice represent a bullous pemphigoid animal model featuring pruritus in immunocompetent, mature, and largely unmanipulated animals.

Original languageEnglish (US)
Pages (from-to)1213-1215
Number of pages3
JournalJournal of Investigative Dermatology
Volume135
Issue number5
DOIs
StatePublished - May 22 2015

ASJC Scopus subject areas

  • Dermatology
  • Biochemistry
  • Cell Biology
  • Molecular Biology

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