KLF13 cooperates with c-Maf to regulate IL-4 expression in CD4+ t cells

Seok Joo Kwon, Juan Crespo-Barreto, Wei Zhang, Tianhong Wang, Dong Seok Kim, Alan Krensky, Carol Clayberger

Research output: Contribution to journalArticle

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Abstract

Kruppel-like factor (KLF) 13 is a transcription factor that positively regulates expression of the chemokine RANTES 3-5 d after activation of T cells. In this study, we document a key role for KLF13 in the expression of IL-4 in CD4+ T cells. Gene expression analysis in activated T cells from Klf13-/- mice showed that IL-4, along with other Th2 cytokine genes, was downregulated when compared with cells from wild-type mice. The decreased levels of IL-4 were not associated with changes in expression of the Th2-inducing transcription factors GATA3 or c-Maf. Additional analysis revealed that KLF13 directly binds to IL-4 promoter regions and synergizes with c-Maf to positively regulate IL-4 expression. These results indicate that KLF13 is a positive regulator for differentiation of Th2 cells, as part of the transcriptional machinery that regulates IL-4 production in Th2 cells.

Original languageEnglish (US)
Pages (from-to)5703-5709
Number of pages7
JournalJournal of Immunology
Volume192
Issue number12
DOIs
StatePublished - Jun 15 2014

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Interleukin-4
Th2 Cells
T-Lymphocytes
GATA3 Transcription Factor
Kruppel-Like Transcription Factors
Chemokine CCL5
Chemokines
Genetic Promoter Regions
Transcription Factors
Down-Regulation
Cytokines
Gene Expression
Genes

ASJC Scopus subject areas

  • Immunology

Cite this

Kwon, S. J., Crespo-Barreto, J., Zhang, W., Wang, T., Kim, D. S., Krensky, A., & Clayberger, C. (2014). KLF13 cooperates with c-Maf to regulate IL-4 expression in CD4+ t cells. Journal of Immunology, 192(12), 5703-5709. https://doi.org/10.4049/jimmunol.1302830

KLF13 cooperates with c-Maf to regulate IL-4 expression in CD4+ t cells. / Kwon, Seok Joo; Crespo-Barreto, Juan; Zhang, Wei; Wang, Tianhong; Kim, Dong Seok; Krensky, Alan; Clayberger, Carol.

In: Journal of Immunology, Vol. 192, No. 12, 15.06.2014, p. 5703-5709.

Research output: Contribution to journalArticle

Kwon, SJ, Crespo-Barreto, J, Zhang, W, Wang, T, Kim, DS, Krensky, A & Clayberger, C 2014, 'KLF13 cooperates with c-Maf to regulate IL-4 expression in CD4+ t cells', Journal of Immunology, vol. 192, no. 12, pp. 5703-5709. https://doi.org/10.4049/jimmunol.1302830
Kwon SJ, Crespo-Barreto J, Zhang W, Wang T, Kim DS, Krensky A et al. KLF13 cooperates with c-Maf to regulate IL-4 expression in CD4+ t cells. Journal of Immunology. 2014 Jun 15;192(12):5703-5709. https://doi.org/10.4049/jimmunol.1302830
Kwon, Seok Joo ; Crespo-Barreto, Juan ; Zhang, Wei ; Wang, Tianhong ; Kim, Dong Seok ; Krensky, Alan ; Clayberger, Carol. / KLF13 cooperates with c-Maf to regulate IL-4 expression in CD4+ t cells. In: Journal of Immunology. 2014 ; Vol. 192, No. 12. pp. 5703-5709.
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