KUZ, a conserved metalloprotease-disintegrin protein with two roles in Drosophila neurogenesis

Jenny Rooke, Duojia Pan, Tian Xu, Gerald M. Rubin

Research output: Contribution to journalArticle

287 Citations (Scopus)

Abstract

During neurogenesis in Drosophila both neurons and nonneuronal cells are produced from a population of initially equivalent cells. The kuzbanian (kuz) gene described here is essential for the partitioning of neural and nonneuronal cells during development of both the central and peripheral nervous systems in Drosophila. Mosaic analyses indicated that kuz is required for cells to receive signals inhibiting the neural fate. These analyses further revealed that the development of a neuron requires a kuz-mediated positive signal from neighboring cells. The kuz gene encodes a metalloprotease-disintegrin protein with a highly conserved bovine homolog, raising the possibility that kuz homologs may act in similar processes during mammalian neurogenesis.

Original languageEnglish (US)
Pages (from-to)1227-1231
Number of pages5
JournalScience
Volume273
Issue number5279
StatePublished - Sep 16 1996

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Disintegrins
Neurogenesis
Metalloproteases
Drosophila
Proteins
Neurons
Peripheral Nervous System
Genes
Central Nervous System
Population

ASJC Scopus subject areas

  • General

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KUZ, a conserved metalloprotease-disintegrin protein with two roles in Drosophila neurogenesis. / Rooke, Jenny; Pan, Duojia; Xu, Tian; Rubin, Gerald M.

In: Science, Vol. 273, No. 5279, 16.09.1996, p. 1227-1231.

Research output: Contribution to journalArticle

Rooke, J, Pan, D, Xu, T & Rubin, GM 1996, 'KUZ, a conserved metalloprotease-disintegrin protein with two roles in Drosophila neurogenesis', Science, vol. 273, no. 5279, pp. 1227-1231.
Rooke, Jenny ; Pan, Duojia ; Xu, Tian ; Rubin, Gerald M. / KUZ, a conserved metalloprotease-disintegrin protein with two roles in Drosophila neurogenesis. In: Science. 1996 ; Vol. 273, No. 5279. pp. 1227-1231.
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