Lack of effect of salt intake on urinary uric acid excretion

N. A. Breslau, C. Y C Pak

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Although it has been established that acute expansion of the extracellular fluid volume results in enhanced uric acid clearance, the effect of chronic volume expansion by a high salt diet on urinary uric acid excretion has not been examined. Eleven normal subjects were placed on a constant diet containing 10 mEq. sodium per day for 10 days, followed by 240 mEq. sodium daily for another 10 days. Measurements were performed on the final 3 days of each phase. Urinary sodium increased from 9 plus or minus 3 standard error to 221 plus or minus 9 mEq. per day (p less than 0.001), and uric acid clearance increased from 5.9 plus or minus 0.4 to 7.1 plus or minus 0.6 ml. per minute (p less than 0.01). However, serum uric acid decreased from 6.4 plus or minus 0.4 to 5.5 plus or minus 0.3 mg/dl. (p less than 0.001). Total urinary excretion of uric acid did not change (533 plus or minus 24 to 535 plus or minus 26 mg. per day). A high salt diet does not result in sustained hyperuricosuria, although it may predispose to kidney stone formation in other ways.

Original languageEnglish (US)
Pages (from-to)531-532
Number of pages2
JournalJournal of Urology
Volume129
Issue number3
StatePublished - 1983

Fingerprint

Uric Acid
Salts
Sodium
Diet
Kidney Calculi
Extracellular Fluid
Serum

ASJC Scopus subject areas

  • Urology

Cite this

Lack of effect of salt intake on urinary uric acid excretion. / Breslau, N. A.; Pak, C. Y C.

In: Journal of Urology, Vol. 129, No. 3, 1983, p. 531-532.

Research output: Contribution to journalArticle

Breslau, N. A. ; Pak, C. Y C. / Lack of effect of salt intake on urinary uric acid excretion. In: Journal of Urology. 1983 ; Vol. 129, No. 3. pp. 531-532.
@article{76183f4dd5ff4df982d3c78e670221f3,
title = "Lack of effect of salt intake on urinary uric acid excretion",
abstract = "Although it has been established that acute expansion of the extracellular fluid volume results in enhanced uric acid clearance, the effect of chronic volume expansion by a high salt diet on urinary uric acid excretion has not been examined. Eleven normal subjects were placed on a constant diet containing 10 mEq. sodium per day for 10 days, followed by 240 mEq. sodium daily for another 10 days. Measurements were performed on the final 3 days of each phase. Urinary sodium increased from 9 plus or minus 3 standard error to 221 plus or minus 9 mEq. per day (p less than 0.001), and uric acid clearance increased from 5.9 plus or minus 0.4 to 7.1 plus or minus 0.6 ml. per minute (p less than 0.01). However, serum uric acid decreased from 6.4 plus or minus 0.4 to 5.5 plus or minus 0.3 mg/dl. (p less than 0.001). Total urinary excretion of uric acid did not change (533 plus or minus 24 to 535 plus or minus 26 mg. per day). A high salt diet does not result in sustained hyperuricosuria, although it may predispose to kidney stone formation in other ways.",
author = "Breslau, {N. A.} and Pak, {C. Y C}",
year = "1983",
language = "English (US)",
volume = "129",
pages = "531--532",
journal = "Journal of Urology",
issn = "0022-5347",
publisher = "Elsevier Inc.",
number = "3",

}

TY - JOUR

T1 - Lack of effect of salt intake on urinary uric acid excretion

AU - Breslau, N. A.

AU - Pak, C. Y C

PY - 1983

Y1 - 1983

N2 - Although it has been established that acute expansion of the extracellular fluid volume results in enhanced uric acid clearance, the effect of chronic volume expansion by a high salt diet on urinary uric acid excretion has not been examined. Eleven normal subjects were placed on a constant diet containing 10 mEq. sodium per day for 10 days, followed by 240 mEq. sodium daily for another 10 days. Measurements were performed on the final 3 days of each phase. Urinary sodium increased from 9 plus or minus 3 standard error to 221 plus or minus 9 mEq. per day (p less than 0.001), and uric acid clearance increased from 5.9 plus or minus 0.4 to 7.1 plus or minus 0.6 ml. per minute (p less than 0.01). However, serum uric acid decreased from 6.4 plus or minus 0.4 to 5.5 plus or minus 0.3 mg/dl. (p less than 0.001). Total urinary excretion of uric acid did not change (533 plus or minus 24 to 535 plus or minus 26 mg. per day). A high salt diet does not result in sustained hyperuricosuria, although it may predispose to kidney stone formation in other ways.

AB - Although it has been established that acute expansion of the extracellular fluid volume results in enhanced uric acid clearance, the effect of chronic volume expansion by a high salt diet on urinary uric acid excretion has not been examined. Eleven normal subjects were placed on a constant diet containing 10 mEq. sodium per day for 10 days, followed by 240 mEq. sodium daily for another 10 days. Measurements were performed on the final 3 days of each phase. Urinary sodium increased from 9 plus or minus 3 standard error to 221 plus or minus 9 mEq. per day (p less than 0.001), and uric acid clearance increased from 5.9 plus or minus 0.4 to 7.1 plus or minus 0.6 ml. per minute (p less than 0.01). However, serum uric acid decreased from 6.4 plus or minus 0.4 to 5.5 plus or minus 0.3 mg/dl. (p less than 0.001). Total urinary excretion of uric acid did not change (533 plus or minus 24 to 535 plus or minus 26 mg. per day). A high salt diet does not result in sustained hyperuricosuria, although it may predispose to kidney stone formation in other ways.

UR - http://www.scopus.com/inward/record.url?scp=0020609389&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020609389&partnerID=8YFLogxK

M3 - Article

C2 - 6834539

AN - SCOPUS:0020609389

VL - 129

SP - 531

EP - 532

JO - Journal of Urology

JF - Journal of Urology

SN - 0022-5347

IS - 3

ER -