Lack of mutations of the human telomerase RNA gene (hTERC) in myelodysplastic syndrome

Kazuma Ohyashiki, Jerry W. Shay, Junko H. Ohyashiki

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Myelodysplastic syndrome (MDS), considered a pre-leukemic state, has recently been categorized as a subset of bone marrow failure syndromes. Unlike other subtypes of bone marrow failure syndromes, such as aplastic anemia or dyskeratosis congenita, little is known about genetic alterations of human telomerase in MDS, despite the fact that immune cells from patients with MDS frequently exhibit telomere attrition.

Original languageEnglish (US)
Number of pages1
JournalHaematologica
Volume90
Issue number5
StatePublished - May 1 2005

Keywords

  • HTERC mutations
  • Myelodysplastic syndrome
  • Telomerase

ASJC Scopus subject areas

  • Hematology

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