Lanthanide chelates as magnetic resonance imaging contrast agents

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Several chelates of Gd3+ are being evaluated for use as magnetic resonance imaging (MRI) contrast agents. This trivalent lanthanide has become the ion chosen for many MRI applications because of its large magnetic moment, long electron-spin relaxation time, and favorable water coordination number and exchange rates. The characteristics of those gadolinium chelates which appear to be safe for use in humans include thermodynamic stability and/or kinetic inertness and a low net negative charge at pH 7.4. Two of the most widely used complexes to date include Gd(DTPA)2- and Gd(DOTA)-. These non-specific blood pool agents distribute throughout the extracellular spaces (both intra- and extravascular) before being cleared through the kidneys. Chelates may also be covalently attached to a macromolecule to restrict the paramagnetic ion in the intravascular space or target it to a particular organ or cell type. Monopropylamide derivatives of DTPA and DOTA, which serve as models for chelate-conjugated proteins, form considerably less stable complexes with Gd3+ without the expected increase in inner-sphere water molecules. The properties of the linear and macrocyclic chelates are compared, and those factors which yield the greatest MRI contrast per dosage of Gd3+ are discussed.

Original languageEnglish (US)
Pages (from-to)133-141
Number of pages9
JournalJournal of the Less-Common Metals
Volume149
Issue numberC
DOIs
StatePublished - Apr 15 1989

Fingerprint

Lanthanoid Series Elements
Magnetic resonance
Rare earth elements
Contrast Media
Imaging techniques
Ions
Pentetic Acid
Gadolinium DTPA
Water
Gadolinium
Magnetic moments
Macromolecules
Relaxation time
Thermodynamic stability
Blood
Derivatives
Proteins
Molecules
Kinetics
Electrons

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Lanthanide chelates as magnetic resonance imaging contrast agents. / Sherry, A. Dean.

In: Journal of the Less-Common Metals, Vol. 149, No. C, 15.04.1989, p. 133-141.

Research output: Contribution to journalArticle

@article{041b58632c704d5588d0970fa16e5391,
title = "Lanthanide chelates as magnetic resonance imaging contrast agents",
abstract = "Several chelates of Gd3+ are being evaluated for use as magnetic resonance imaging (MRI) contrast agents. This trivalent lanthanide has become the ion chosen for many MRI applications because of its large magnetic moment, long electron-spin relaxation time, and favorable water coordination number and exchange rates. The characteristics of those gadolinium chelates which appear to be safe for use in humans include thermodynamic stability and/or kinetic inertness and a low net negative charge at pH 7.4. Two of the most widely used complexes to date include Gd(DTPA)2- and Gd(DOTA)-. These non-specific blood pool agents distribute throughout the extracellular spaces (both intra- and extravascular) before being cleared through the kidneys. Chelates may also be covalently attached to a macromolecule to restrict the paramagnetic ion in the intravascular space or target it to a particular organ or cell type. Monopropylamide derivatives of DTPA and DOTA, which serve as models for chelate-conjugated proteins, form considerably less stable complexes with Gd3+ without the expected increase in inner-sphere water molecules. The properties of the linear and macrocyclic chelates are compared, and those factors which yield the greatest MRI contrast per dosage of Gd3+ are discussed.",
author = "Sherry, {A. Dean}",
year = "1989",
month = "4",
day = "15",
doi = "10.1016/0022-5088(89)90480-3",
language = "English (US)",
volume = "149",
pages = "133--141",
journal = "Journal of Alloys and Compounds",
issn = "0925-8388",
publisher = "Elsevier BV",
number = "C",

}

TY - JOUR

T1 - Lanthanide chelates as magnetic resonance imaging contrast agents

AU - Sherry, A. Dean

PY - 1989/4/15

Y1 - 1989/4/15

N2 - Several chelates of Gd3+ are being evaluated for use as magnetic resonance imaging (MRI) contrast agents. This trivalent lanthanide has become the ion chosen for many MRI applications because of its large magnetic moment, long electron-spin relaxation time, and favorable water coordination number and exchange rates. The characteristics of those gadolinium chelates which appear to be safe for use in humans include thermodynamic stability and/or kinetic inertness and a low net negative charge at pH 7.4. Two of the most widely used complexes to date include Gd(DTPA)2- and Gd(DOTA)-. These non-specific blood pool agents distribute throughout the extracellular spaces (both intra- and extravascular) before being cleared through the kidneys. Chelates may also be covalently attached to a macromolecule to restrict the paramagnetic ion in the intravascular space or target it to a particular organ or cell type. Monopropylamide derivatives of DTPA and DOTA, which serve as models for chelate-conjugated proteins, form considerably less stable complexes with Gd3+ without the expected increase in inner-sphere water molecules. The properties of the linear and macrocyclic chelates are compared, and those factors which yield the greatest MRI contrast per dosage of Gd3+ are discussed.

AB - Several chelates of Gd3+ are being evaluated for use as magnetic resonance imaging (MRI) contrast agents. This trivalent lanthanide has become the ion chosen for many MRI applications because of its large magnetic moment, long electron-spin relaxation time, and favorable water coordination number and exchange rates. The characteristics of those gadolinium chelates which appear to be safe for use in humans include thermodynamic stability and/or kinetic inertness and a low net negative charge at pH 7.4. Two of the most widely used complexes to date include Gd(DTPA)2- and Gd(DOTA)-. These non-specific blood pool agents distribute throughout the extracellular spaces (both intra- and extravascular) before being cleared through the kidneys. Chelates may also be covalently attached to a macromolecule to restrict the paramagnetic ion in the intravascular space or target it to a particular organ or cell type. Monopropylamide derivatives of DTPA and DOTA, which serve as models for chelate-conjugated proteins, form considerably less stable complexes with Gd3+ without the expected increase in inner-sphere water molecules. The properties of the linear and macrocyclic chelates are compared, and those factors which yield the greatest MRI contrast per dosage of Gd3+ are discussed.

UR - http://www.scopus.com/inward/record.url?scp=0024648385&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024648385&partnerID=8YFLogxK

U2 - 10.1016/0022-5088(89)90480-3

DO - 10.1016/0022-5088(89)90480-3

M3 - Article

AN - SCOPUS:0024648385

VL - 149

SP - 133

EP - 141

JO - Journal of Alloys and Compounds

JF - Journal of Alloys and Compounds

SN - 0925-8388

IS - C

ER -